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Σκομπρίδης Κων/νος

KONSTANTINOS SKOBRIDIS

Professor

 

E-Mail:kskobrid@cc.uoi.gr

 

Phone: ( +30) 26510 08598

 

Fax: (+30) 26510 08670

 

Address: Panepistimiopolis Douroutis, Department of Chemistry, 451 10 Ioannina

 

 

Education-Career/Employment

 

1987:               B.S., Chemistry, Chemistry Department, Rheinische Friedrich Wilhelms University of Bonn, Germany

1991:               Ph.D., Chemistry, Chemistry Department, Rheinische Friedrich Wilhelms University of Bonn, Germany

 

1992-1993:      Postdoc, Eidgenössische Technische Hochshule (ETH) Zürich, Schwitzerland

1993-1995:      Central Research Laboratories, Ciba, Basel, Schwitzerland

1996-2001:      General Chemical State Laboratory of Greece, Ioannina, Greece

2001-2005:      Lecturer, Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece

2006-2010:      Assistant Professor, Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece

2010-present:  Associate Professor, Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece

 

 

Research

 

- Design, synthesis, characterization (1H-NMR, MS, etc), properties and applications of host-guest inclusion compounds.

- Macromolecules. Design and synthesis of dendrimers and dendrimer conjugates with calixarens, crown-ethers, etc, properties and applications.

- Design and synthesis of novel organic compounds with biological activity. Selective inhibitors of protein kinases.

- Development of new synthetic methods. Mechanistic studies of organic reactions

 

Teaching

Undergraduate

Organic Chemistry II,IV,V, Laboratory of Organic Chemistry I and II, Literature and Laboratory Research

 

Graduate

Advanced Lectures in Organic Chemistry (Retrosynthetic Analysis), Structure and Mechanisms in Organic Chemistry

 

 

List of selected publications

1.       E. Weber, K. Skobridis, M. Ouchi, T. Hakushi and Y. Inone

Polytropic Cation Receptors. Di- and Triloop Crown Hosts Having Aromatic Junctions. Synthesis, Cation Extraction, and Solid Complex Formation. Bull. Chem. Soc. Jpn., 1990, 63 (12), 3670-3677.

2.         E. Weber, K. Skobridis, A. Wierig, S. Stathi and L. R. Nassimbeni

A New Atropisomeric Molecular Structure for Efficient Enantiodifferentiation

Angew. Chem. Int. Ed. Engl. 1993, 32 (4), 606-608.

3.         J.-M. Lapierre, K. Skobridis and D. Seebach

Preparation of Chiral Building Blocks for Starburst Dendrimer Synthesis. Helv. Chim. Acta 1993, 76 (7), 2419-2432.

4.         D. Seebach, J.-M. Lappiere, K. Skobridis and G. Greiveldinger

Chiral Dendrimers from Tris(hydroxymethyl)-methane Derivatives, Angew. Chem. Int. Ed. Engl. 1994, 33 (4), 440-442.

5.         D. Seebach, J.-M. Lapierre, G. Greiveldinger and K. Skobridis

Synthesis of Chiral Starburst Dendrimers from PHB-Derived Triols as Central Cores. Helv. Chim. Acta 1994, 77 (7), 1673-1688.

6.         V. Thedorou and K. Skobridis

An Unexpected Base-induced Rearrangement of Tritylamine. Tetrahedron Lett. 2005, 46 (30), 5021-5023.

7.         K.Skobridis, D. Hüsken, P. Nicklin and R. Häner

Hybridization and Cellular Uptake Properties of Lipophilic Oligonucleotide-dendrimer Conjugates”. Arkivoc 2005, part(vi), 459-469.

8.         K. Skobridis, V. Theodorou and E. Weber

A Very Simple and Chemoselective Air Oxidation of Benzoins to Benzils by Use of Alumina. Arkivoc 2006, part(x), 102-106.

9.         D. Alivertis, V. Theodorou, G. Paraskevopoulos, K. Skobridis

Searching for new host compounds: synthesis and characterization of novel crown ether-functionalized dendrimers. Tetrahedron Lett. 2007, 48 (23), 4091-4095.

10.       V. Theodorou, K. Skobridis, A. Karkatsoulis 

Base-induced rearrangement of tritylamines to imines: discovery and investigation of the mechanism. Tetrahedron  2007, 63 (20), 4284-4289.

11.       V. Theodorou, K. Skobridis, A.G. Tzakos, V. Ragoussis

A simple method for the alkaline hydrolysis of esters. Tetrahedron Lett. 2007, 48 (46), 8230-8233.

12.       Alivertis, G. Paraskevopoulos, V. Theodorouand, K. Skobridis

Dendritic effects of crown ether-functionalized dendrimers on the solvent extraction of metalions. Tetrahedron Lett. 2009, 50 (44), 6019-6021.

 

13.      V. Theodorou, A. Karkatsoulis, M. Kinigopoulou, V. Ragoussis, K. Skobridis

Tritylamine as an ammonia synthon: Preparation of primary amides. Arkivoc 2009, part (xi), 277-287.

14.       K. Skobridis, M. Kinigopoulou, V. Theodorou, E. Giannousi, A. Russell, R. Crozier, N. Brownlow, S. Kiriakidis, J. Domin, A. Tzakos, N. J. Dibb

Novel imatinib derivatives with altered specificity for Bcr-Abl and FMS, KIT, and PDGF receptors. Chem. Med.Chem. 2010, 5(1), 130-139.

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