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Varvounis George

Professor

Email: gvarvoun@cc.uoi.gr

Phone: (+30) 26510-(08382 or 08708)

Fax: (+30) 26510-08799

Address: Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Panepistimioupoli Dourouti, 451 10 Ioannina, Greece.

 

 

Education

1974-1977:

B.Sc. Honours in Chemistry and Biochemistry from the Life Sciences Department, Polytechnic of Central London, England, U.K.

 

1977-1979:

M.Sc. in Applied Heterocyclic Chemistry from the Department of Chemistry and Applied Chemistry, University of Salford, England, U.K.

1977-1981:

Laboratory Teaching Assistant at the Department of Chemistry and Applied Chemistry, University of Salford, England, U.K.

 

1979-1982:

Ph.D. in Chemistry from the Department of Chemistry and Applied Chemistry, University of Salford, England, U.K.

 

1982-1990:

Lecturer at the Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece.

 

1983-1987:

Postdoctoral fellow, Department of Chemistry, Queen Elizabeth College, University of London, England, U.K. (total period of 15 months).

 

1988-1994:

Sabbatical leave, Department of Chemistry and Applied Chemistry, University of Salford, England, U.K. and Department of Chemistry, Kings College London, University of London, England, U.K. (total period of 12 months).

 

1990-2001:

Assistant Professor at the Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece.

 

2001-2012:

 

23-08-2012:

to today

Associate Professor at the Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece.

Professor at the Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece.

 

 

Research

  —     

Design, synthesis, and study of the chemical properties of novel heterocyclic compounds of pharmacological interest.

We are interested in developing novel synthetic methodologies that will be applied in the area of heterocyclic ring formation, particularly for the synthesis of pyrrole, imidazole and indole derivatives of natural products or pharmacologically active compounds. One aspect of this research is identified by our efforts towards finding promising drugs against AIDS and is focused on synthesizing non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Compounds exhibiting this activity include diarylsulfones, pyrrolobenzo-thiazepines, as well as pyrrolobenzo-thiadiazocines. We also have strong interest in the synthesis of analogues of the pyrrolo[2,1-c][1,4]benzodiazepine family of anti-tumour antibiotics such as anthramycin, DC-81 and abbeymycin. These natural products have shown strong cytotoxic and anti-tumour effects believed to arise from interaction with DNA. Certain pyrrolo[2,1-c][1,4]benzo-diazepines, such as VPA-985, are known to be orally active arginine vasopressin antagonists with selectivity for V2 receptors may be potentially useful for treating diseases characterized by excess renal reabsorption of free water. In this area of research we are interested in the synthesis of novel imidazo- and pyrrolo-benzodiazepines.

  —     

Design, synthesis, and study of the chemical properties of trihalomethyl substituted aromatic and heteroaromatic compounds.

Nucleophilic aromatic substitution in carbocyclic and heterocyclic arenes is a very important reaction from both the academic and industrial point of view. Tele nucleophilic substitution is the reaction where an entering group occupies a position on the arene or heteroarene that is two or more bonds distant from the atom to which the leaving group is bonded. For this type of useful and exciting chemistry we require 3-(trichloromethyl)- pyridine, quinoline, nitrobenzene, nitronaphthalene, benzonitrile and naphthonitrile derivatives, as starting materials. One of our targets is the synthesis of the naturally occurring cereal hydroxamic acid, 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA), which exhibits interesting biological properties, such as phytotoxic, antimicrobial, antifeedant, antifungal, and insecticidal properties. On this line of work we aim to investigate the chemistry of trichloromethyl analogues of DIMBOA and other closely related natural products.

  —    

Design, synthesis, and study of the chemical properties of hydrazones and oximes of o-hydroxyarylaldehydes and ketones.

Oxidative ring closure is an important tool for synthesizing a plethora of 5- and 6-membered heterocycles. In recent years there has been a rich development of both selective and mild oxidation methods that have found important applications in synthetic organic chemistry, that are useful for industry. Our research in this area of chemistry involves the oxidative cyclisation of hydrazones and oximes of o-hydroxyarylaldehydes and ketones. We have incorporated the medicinally important isoxazole, 1,2,5-oxadiazole, indole and pyran rings into novel polyheterocyclic systems. In parallel we are investigating the in situ oxidative generation of 1,3-dipoles from appropriately substituted hydrazones and oximes of o-hydroxyarylaldehydes and ketones leading to intra- or intermolecular cycloaddition reactions with alkenes or alkynes.

  —     

Study of novel methods for the in situ generation of o-(naphtho)quinone methides and o-(naphtho)quinone nitrosomethides. Michael and Diels-Alder reactions.

 The in situ generation of reactive intermediates such as o-(naphtho)quinone methides have attracted recently our attention. We presented a new method of producing these transient species from benzo and naphtho precursors bearing methylnitrate and tertbutyldimethyl-silyloxy substituents at adjacent positions of the aromatic ring. The method of o-(naphtho)quinone methide generation involves fluoride anion nucleophilic cleavage of the silyloxy σ-bond by n-tetrabutylammonium fluoride followed by concomitant elimination of a nitrate anion. The intermediate o-(naphtho)quinone methides were trapped by nucleophiles and dienophiles showing the wide applicability of this method. We are now studying the possibility of generating o-(naphtho)quinone nitrosomethides and are searching for applications in drug chemistry.

 

  —     

Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines as inhibitors for hGSTA1-1.

Glutathione transferases (GSTs) are important enzymes to the medical community because of their xenobiotic and drug detoxifying function. Several synthetic drugs and prodrugs, other than pyrrole derivatives, displaying GST inhibition have been proposed as strategies to overcoming multiple drug resistance due to GST overexpression in tumour cells. We have filed the first report on pyrrole derivatives as inhibitors of the medically important human isoenzyme hGSTA1-1. The most active of these derivatives is 2-{[(1-methyl-1H-pyrrol-2-yl)sulfonyl]methyl}-N-[(1E)-(4-nitrophenyl)methylene]aniline that we are now using as a ‘lead structure’ useful for designing new inhibitors and pro-drugs for human GSTs.

 

Scientific Awards

-Award by the International Scientific Foundation για το "Contribution to World Science and International Scientific Collaboration" (2006).

-Award by the International Scientific Foundation the "Gold Badge για Scientific Achievements and International Scientific Collaboration" (2010)

 Patents

Varvounis,     Georgios.     A     preparation   of       [[(chloro-phenyl)(phenyl)methyl]piperazinyl]ethoxyacetic acid (cetirizine) and its dihydrochloride. Industrial Property Organization, Greek Pat. Appl. 99100135 (2000), 12 pp.)

Teaching

Undergraduate Subjects

Organic Chemistry I-ΙV, Laboratory of Organic Chemistry I and II, Advanced Organic Synthesis Laboratory, Literature or/and Laboratory Research Project, Natural Products and Heterocyclic Compounds.

Graduate Subjects

Bioorganic Chemistry (Chapter on: Anti-cancer compounds, synthesis and interaction with DNA), Advanced Lectures in Organic Chemistry (Chapters on: Synthesis of indolizomycin and penicillin V), Applied Heterocyclic Chemistry, Postgraduate Laboratory of Organic Chemistry.

List of Scientific Publications in International Journals and Chapters in International Scientific Book Series

1. Clark, J.; Varvounis, G. Heterocyclic Studies. Part 42. Pyrimido[5,4-d]-[1,2,3]triazines and some Related Tricyclic Compounds. J. Chem. Soc. Perkin Trans. 1, 1984, 1475-1481.

2. Cheeseman, G.W.H.*; Hawi, A. A.; Varvounis, G. Synthesis of 5,6-Dihydropyrrolo[1,2-a][3,1,6]-benzothiadiazocines. J. Heterocycl. Chem. 1985, 22, 423-427.

3. Clark, J.; Varvounis, G.; Bakavoli, M. Heterocyclic Studies. Part 44. Novel Tricyclic Compounds containing the Pyrimido[5,4-d][1,2,3]triazine System. J. Chem. Soc. Perkin Trans. 1 1986, 711-719.

4. Cheeseman, G.W.H.*; Varvounis, G. Synthesis and Reactions of Pyrrolo[1,2-a][3,1,6]benzothiadiazocines. J. Heterocycl. Chem. 1987, 24, 1157-1161.

5. Yakovidis, G.; Varvounis, G.; Hadjiliadis, N.* Copper(II) Complexes of Thieno[2,3-d]-pyrimidine Derivatives. Inorg. Chim. Acta 1988, 151, 165-167.

6. Cheeseman, G.W.H.*; Varvounis, G. Synthesis of some Pyrrolobenzothiadiazocines. J. Heterocycl. Chem. 1988, 25, 431-435.

7. Dainter, R.S.; Jackson, T.; Omar, A.H.H.; Suschitzky, H.; Wakefield, B.J.*; Hughes, N.; Nelson, A.J.; Varvounis, G. Transformations of Trichloromethyl Groups During Reactions of 3-Trichloromethylpyridines with Methoxide. J. Chem. Soc. Perkin Trans. 1 1989, 283-287.

8. Cobb, J.; Cheeseman, G.W.H.*; Varvounis, G. The use of NMR Measurements in the Orientation of Pyrrolic Substitution in 5,6-Dihydro-7-methyl-6-oxopyrrolo[1,2-a][3,1,6]benzothiadiazocine. J. Heterocycl. Chem. 1989, 26, 81-83.

9. Cobb, J.; Demetropoulos, I.N.; Skoulika, S.; Varvounis, G.*; Aubry, A. Structure Determination of some 5,6-Dihydropyrrolo[1,2-a][3,1,6]-benzothiadiazocines. J. Heterocycl. Chem. 1992, 29, 295-303.

Clark, J.; Korakas, D.; Shahhet, M.S.; Varvounis, G.* Synthesis of Thieno[2,3-d]pyrimidines from 4,6-Dichloropyrimidine-5-carbaldehydes. J. Heterocycl. Chem. 1993, 30, 1065-1072.

10. Korakas, D.; Varvounis, G.* A Convenient Synthesis of 2-Aminomethyl-1-arylpyrroles. Synthesis 1994, 164-166.

11. Korakas, D.; Varvounis, G.* Synthesis of 5,6-Dihydro-4H-pyrrolo[1,2-a]-[1,4]benzodiazepine and 10,11-Dihydro-5H,12H-pyrrolo[2,1-c][1,4]benzo-diazocine Derivatives via Cyclisation of 2-Amino-methylpyrroles. J. Heterocycl. Chem. 1994, 31, 1317-1320.

12. Tsiveriotis, P.; Varvounis, G.; Papadimitriou, C.; Hadjiliadis, N.* Nickel(II) and Cobalt(II) Complexes of 2,4-Diaminothieno[2,3-d]pyrimidines. Transition Met. Chem. 1994, 19, 335-339.

13. Cartwright, D.; Ferguson, J.R.; Giannopoulos, T.; Varvounis, G.*; Wakefield, B.J.* Synthesis of some β-Trichloromethyl-azines and -diazines. J. Chem. Soc., Perkin Trans. 1, 1995, 2595-2597.

14. Cartwright, D.; Ferguson, J.R.; Giannopoulos, T.; Varvounis, G.*; Wakefield, B.J.* Abnormal Nucleophilic Substitution in 3-Trichloro-methylpyridine, its N-oxide and 3,5-Bis-(trichloro-methyl)pyridine. Tetrahedron 1995, 51, 12791-12796.

15. Cobb, J.; Demetropoulos, I.N.; Korakas, D.; Skoulika, S.; Varvounis, G.* Synthesis and Reactions of 1-Aryl-2-nitropyrroles. Structural and Conformational Study of Ethyl N-[2΄-[1΄-(2-nitropyrrolyl)]-phenyl]-N-toluene-4-sulfonamide glycinate. Tetrahedron 1996, 52, 4485-4494.

16. Gerothanassis, I.P.*; Cobb, J.; Kimbaris, A.; Smith, J.A.S.; Varvounis, G. 17O and 14N NMR Studies of Quinoxaline-2,3-diones and N,N΄-Substituted Oxamides: the First Experimental Evidence of Torsion Angle Deformation Resulting from an Unprecedented through Six-Bond Substituent Effect of the Diamide Group of Quinoxaline-2(1H),3(4H)-diones. Tetrahedron Lett. 1996, 37, 3191-3194.

17. Korakas, D.; Varvounis, G.* The Nitration of some 1-Aryl(or benzyl)-pyrroles. J. Heterocycl. Chem. 1996, 33, 611-614.

18. Gerothanassis, I.P.*; Varvounis, G. 17O NMR Studies of Electronic and Steric Interactions of Substituted Quinoxaline-2(1H),3(4H)-diones. J. Heterocycl. Chem. 1996, 33, 643-646.

19. Varvounis, G.; Giannopoulos, T. Synthesis, Chemical and Biological Properties of Thieno[2,3-d]pyrimidines. “Advances in Heterocyclic Chemistry”, Katritzky, A. R. (ed.); Academic Press Inc. 1996; vol. 66, pp 193-283.

20. Varvounis, G. Boroles. “Comprehensive Heterocyclic Chemistry I”, Katritzky, A.R.; Rees, C.W.; Scriven, E.F.V. (eds.); Pergamon, Oxford, 1996; vol. 2, pp 919-932.

21. Korakas, D.; Kimbaris, A.; Varvounis, G.* Synthesis of the Novel Pyrrolo[2,1-d][1,2,5]benzotriazepine, Pyrrolo[2,1-e][1,3,6]benzotriazocine and Pyrrolo[1,2-a]tetrazolo[1,5-d][1,4]benzodiazepine Ring Systems. A New Route to Pyrrolo[1,2-a]quinoxaline via Transamination of in Situ Generated 1-(2-Aminophenyl)-2-iminomethylpyrroles. Tetrahedron 1996, 52, 10751-10760.

22. Giannopoulos, T.; Ferguson, J.R.; Wakefield, B.J.; Varvounis, G.* Tele Nucleophilic Aromatic Substitutions in 1-Nitro-3- and 1,3-Dinitro-5-trichloro-methylbenzene, and 3-Trichloromethylbenzonitrile. A New Synthesis of the 1,4-benzothiazine-3(4H)-one Ring System from 3-Nitrobenzoic acid. Tetrahedron 2000, 56, 447-453.

23. Supsana, P.; Tsoungas, P.G.; Varvounis, G.* A Novel One-pot Synthesis of Isomeric Naphtho[1,2-d]isoxazole-2-oxide and Naphtho[1,8-de][1,2]oxazine Ring Systems. A Case of Simultaneous O- and Peri- Cyclisation in Naphthalene. Tetrahedron Lett. 2000, 41, 1845-1847.

24. Kimbaris, Α.; Varvounis, G.* Reduction of 2- and 3-Acylpyrroles. A New Synthesis of the Pyrrolo[1,2-b]cinnolin-10-one Ring System from 1-(4-Μethylphenyl)sulfonyl-1H-pyrrole. Tetrahedron 2000, 56, 9675-9683.

25. Supsana, P.; Tsoungas, P.G.; Aubry, A.; Skoulika, S.; Varvounis, G.* Oxidation of 1- Acyl-2-Naphthol Oximes: Peri- and/or O-Cyclisation and/or Spiro Cyclodimerisation of O-Nitrosoquinone methide Intermediates. Tetrahedron 2001, 57, 3445-3453.

26. Varvounis, G.; Fiamegos, Y.; Pilidis, G. Pyrazol-3-ones. Part 1: Synthesis and Applications. “Advances in Heterocyclic Chemistry”, Katritzky, A. R. (ed.); Academic Press Inc. 2001; vol. 80, pp 73-156.

27. Fiamegos, Y.C.; Pilidis, G.A.; Varvounis, G.* Synthesis of 1-methyl-, 4-nitro-, 4-amino- and 4-iodo-1,2-dihydro-3H-pyrazol-3-ones. J. Heterocycl. Chem. 2001, 28, 1065-1069.

28. Mąkosza, M.*; Varvounis, G.*; Surowiec, M.; Giannopoulos, T. Tele-vs. Oxidative Substitution of Hydrogen in meta Monochloromethyl, Dichloromethyl, and Trichloromethyl Nitrobenzenes in the Reaction with Grignard Reagents. Eur. J. Org. Chem. 2003, 3791-3797.

29. Kimbaris, Α.; Cobb, J.; Tsakonas, G., Varvounis, G.* Novel pyrrolo[1,2-a]-[3.1.6]benzothiadiazocine ring synthesis. Unusual Truce-Smiles type rearrangement of 1-{[1-(2-nitrophenyl)-1H-pyrrol-2-yl]sulfonyl(or sulfinyl)}acetone. Tetrahedron 2004, 60, 8807-8815.

30. Varvounis, G.; Fiamegos, Y.; Pilidis, G. Pyrazol-3-ones. Part II: Reactions of the Ring Atoms. “Advances in Heterocyclic Chemistry”, Katritzky, A.R. (ed.); Academic Press Inc. 2004; vol. 87, pp 141-272.

31. Rotas, G.; Kimbaris, A.; Varvounis, G.* Synthesis of 5-alkyl(or aryl)pyrrolo[1,2-a]quinoxalin-4-(5H)-ones by denitrocyclisation of N-alkyl(or aryl)-1-(2-nitrophenyl)-1H-pyrrole-2-carboxamides. Evidence of a Smiles rearrangement. Tetrahedron 2004, 60, 10825-10832.

32. Supsana, P.; Liaskopoulos, T.; Skoulika, S.; Kolocouris, A.; Tsoungas, P.G.; Varvounis, G.* A spiro[naphthalene(naphthopyranofuroxan)] to spiro[naphtha-lene(phenalenofurazan) thermal rearrangement. A probable furoxan-triggered tandem isomerisation process. Tetrahedron 2005, 61, 6131-6137.

33. Rotas, G.; Natchkebia, K.; Natsvlishvili, N.; Kekelidze, M.; Varvounis, G.*; Mikeladze, D.* Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells. Bioorg. Med. Chem. Lett. 2005, 15, 3220-3223.

34. Bissyris, E.E.; Belekos, D.; Magafa, V.; Tsoungas, P.G.; Varvounis, G.*; Cordopatis, P.* 2-Amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid as an N-terminal surrogate in amino acid and peptide analogues. Synthesis 2005, 3159-3166.

35. Varvounis, G.; Karousis, N. Functions Containing Two Halogens and Two Other Heteroatom Substituents, “Comprehensive Organic Functional Group Trans-formations II” (COFGT-II), A.R. Katritzky, R.J.K. Taylor, E.F.V. Scriven (eds.); Elsevier Oxford. 2005; vol. 6. pp 271-294.

36. Karousis, K.; Liebscher, J.*; Varvounis, G.* Synthesis of (E)-3-1H-Pyrrol-3-yl]-2-propene derivatives using Organophosphorus Reagents. Synthesis 2006, 1494-1498.

37. Vergadou, V.; Pistolis, G.*; Michaelides, Α.; Varvounis, G.; Siskos, M.; Boukos, N.; Skoulika, S.* Self-organization of Four Symmetric Triphenylbenzene Derivatives. Cryst. Growth Des. 2006, 6, 2486-2492.

38. Supsana, P.; Liaskopoulos, T.; Tsoungas, P.G.; Varvounis, G.* DMF-Catalysed Thermal Dehydration of Aldoximes: A Convenient Access to Functionalised Aliphatic and Aromatic Nitriles. Synlett 2007, 2671-2674.

39. Varvounis, G.; Fiamegos, Y.; Pilidis, G. Pyrazol-3-ones. Part III: Reactions of the Ring Substituents. “Advances in Heterocyclic Chemistry”, Katritzky, A. R. (ed.); Academic Press Inc. 2008; vol. 95, pp 27-141.

40. Liaskopoulos, T.; Skoulika, S.; Tsoungas, P.G.; Varvounis, G.* Novel Synthesis of Naphthopyranoisoxazoles and Versatile Access to Naphthopyrano-isoxazolines. Synthesis 2008, 711-718.

41. Karousis, N.; Koriatopoulou, K.; Varvounis, G.* Synthesis of 1-aroyl-methylpyrroles as useful intermediates for further chemical transformation. Arkivoc 2008, (ii), 124-133.

42. Varvounis, G. Boroles. “Comprehensive Heterocyclic Chemistry III”, Katritzky, A.R.; Ramsden, C.A.; Scriven, E.F.V.; Taylor, R.J.K. (eds.); Elsevier Oxford. 2008; vol. 3, pp 1225-1241.

43. Varvounis, G. Five-Membered Rings with Two Nonadjacent Heteroatoms with at least One Boron. “Comprehensive Heterocyclic Chemistry III”, Katritzky, A.R.; Ramsden, C.A.; Scriven, E.F.V.; Taylor, R.J.K. (eds.), Elsevier Oxford., 2008; vol. 4, pp 1225-1241.

44. Koriatopoulou, K.; Karousis, N.; Varvounis, G.* A novel synthesis of the pyrrolo[2,1-c]-[1,4]benzodiazocine ring system via a Dieckmann condensation. Tetrahedron 2008, 64, 10009-10013.

46. Varvounis, G. Pyrazol-3-ones. Part IV: Synthesis and Applications. “Advances in Heterocyclic Chemistry”, Katritzky, A.R. (ed.); Academic Press Inc. 2009; vol. 98, pp 143-223.

47. Odrowaz-Sypniewski, M.R.; Tsoungas, P.G.*; Varvounis, G.; Cordopatis, P. Xanthone in synthesis: a reactivity profile via directed lithiation of its dimethyl ketal. Tetrahedron Lett. 2009, 50, 5981-5983.

48. Dolka, C.; Hecke, K.V.; Meervelt, L.C.; Petros G. Tsoungas, P.G.; Van der Eycken, E.V.*; Varvounis, G.* Novel Thermal and Microwave-Assisted Facile Route to Naphthalen-2(1H)-ones via an Oxidative Alkoxylation-Ring-Opening Protocol. Org. Lett. 2009, 11, 2964-2967.

49. Assimomytis, Ν.; Sariyannis, Y.; Stavropoulos, G.; Tsoungas, P.G.*; Varvounis, G.; Cordopatis, P. Anionic ortho-Fries rearrangement, a facile route to arenol–based Mannich bases. Synlett, 2009, 2777-2782.

50. Surowiec, M.; Belekos, D.; Mąkosza, M.*; Varvounis, G.* Tele Nucleophilic Substitutions of Hydrogen in m-(Trichloromethyl)nitrobenzenes with Cyano and Ester Carbanions. Eur. J. Org. Chem. 2010, 3501-3506.

51. Rotas, G.; Kimbaris, A.; Varvounis, G.* Synthesis of a novel pyrrolo[1,2-c][1.3]benzodiazepine analogue of VPA-985. Tetrahedron, 2011, 67, 7805-7810.

52. Shaikh, Α.Κ.; Cobb, A.J.A.; Varvounis, G.* Mild and Rapid Method for the Generation of ortho-(Naphtho)quinone Methide Intermediates. Org. Lett. 2012, 14, 584-587.

53. Koutsoumpli, G. E.; Dimaki, V. D.; Thireou, T. N.; Eliopoulos, E. E.; Labrou, N. E.; Varvounis, G. I.; Clonis, Y. D. Synthesis and Study of 2-(Pyrrolesulfonylmethyl)-N-arylimines: A New Class of Inhibitors for Human Glutathione Transferase A1-1. J. Med. Chem. 2012, 55, 6802-6813.

List of Scientific Publications in International Journals and Book Series from Conference Book of Abstracts

1. 17O NMR studies of electronic and steric interactions of 2,3(1H,4H)quinoxalinedione. Spectroscopy of Biological Molecules: Modern Trends, [European Conference on Spectroscopy of Biological Molecules], 7th, Madrid, Gerothanassis, I. P.; Varvounis, G. 1997, 623-624.

2. Kimbaris, A.; Cobb, J. Varvounis, G. A New Synthesis of the Pyrrolo[1,2-a][3,1,6]-benzothiadiazocine Ring System from 1-{[1-(2-nitrophenyl)-1H-pyrrol-2-yl]sulfinyl} derivatives. Fifth International Electronic Conference on Synthetic Organic Chemistry (ECSOC-5). 2001, http://www.mdpi.org/ecsoc-5.htm

3. Dolka, C.; Dimaki, V.; Tsoungas, P. G.; Varvounis, G. Synthesis and/or reactivity of novel pyrrole, indole, 1,2-benzisoxazole, phthalazine, xanthone and naphthalen-2(1H)-one derivatives of potential pharmacological interest. Med. Chem. Res. 2010, 19, Suppl. 1, 37-38.

4. Manessi-Zoupa, E. M. Z.; Exarchakou, R.; Magafa, V.; Assimomytis, N.; Liapakis, G.; Venihaki, M.; Varvounis, G.; Cordopatis, P. Synthesis And Biological Evaluation Of New Linear And Cyclic Analogues Of Neurotensin. J. Pept. Sci. 2010, 16, Suppl. 1, 159.

 

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