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Γεροθανάσης Ιωάννης

Professor Ioannis P. Gerothanassis

University of Ioannina

Department of Chemistry

Section of Organic Chemistry and Biochemistry

45110, Ioannina, Greece

tel. 26510 08389

fax: 26510 08799

e-mail: igeroth@cc.uoi.gr

 

Biographical Sketch

  • Year of birth: 1952
  • Nationality: Greek
  • 1974 (1975: year of award): BSc Degree in Chemistry, Aristotle Univ. of Thessaloniki, Greece.
  • 1975-1977: Military service.
  • 1977: 3 years fellowship from the Greek Scholarship Foundation for postgraduate studies in England.
  • 1978 (1979: year of award): MSc degree in Chemical Spectroscopy in the School of Chemical Sciences, Univ. of East Anglia, Enland.
  • 1980 (1981: year of award): PhD thesis, School of Chemical Sciences, Univ. of East Anglia, England.
  • 1980: Postdoctorate fellowship from the “Swiss Fond National” for NMR Biophysical Research in the Univ. of Lausanne, Institute of Organic Chemistry, Switzerland.
  • 1981-1984: “Premier Assistant”, Univ. of Lausanne, Institute of Organic Chemistry, Switzerland.
  • 1984: Lecturer, Section of Physical Chemistry, Dept. of Chemistry, School of Natural Sciences, University of Ioannina (UoI), Greece.
  • 1986: Assistant Professor, Section of Organic Chemistry and Biochemistry, Dept. of Chemistry, UoI, Greece.
  • 1990: Associate Professor in the same Department.
  • October 1994: Honorary Research Fellow of the Queen Mary College, Univ. of London.
  • September 1997: Full Professor, Dept. of Chemistry, UoI.
  • September 1997-August 2000: Head of the Section of Organic Chemistry and Biochemistry, Dept. of Chemistry, UoI.
  • September 1998-August 2000: Vice Chairman of the Dept. of Chemistry, UoI.
  • September 2000-August 2004: Chairman of the Dept. of Chemistry, UoI.
  • September 2003-August 2006: Vice Rector of the UoI.
  • June 2004-June 2005: Chairman of the Dept. of Biological Applications and Technologies, UoI.
  • September 2006-August 2010: Rector of the UoI.
  • June 2007-September 2010: Chairman of the Dept. of Plastic Arts and Art Sciences, UoI.
  • June 2009-September 2010: Chairman of the recently founded Dept. of Architecture Engineering, UoI.
  • September 2010-August 2014: Member of the Hellenic Quality Assurance and Accreditation Agency for Higher Education (HQAA), Athens, Greece.
  • July 2011: DSc, Univ. of East Anglia, England.
  • July 2014-present: Vice Chairman of HQAA.

Post Graduate Studies

  • Master Degree. Title: Natural Abundance Oxygen-17 Fourier Transform NMR Studies, pp.1-196 (1978), School of Chemical Sciences, Univ. of East Anglia, England.
  • PhD Thesis. Title: Studies of 17O NMR Spectroscopy, pp.1-259 (1980), School of Chemical Sciences, Univ. of East Anglia, England.

Scientific Fields

Bioorganic Chemistry, Structural Biology, NMR Spectroscopy, Food Chemistry, Natural Product Analysis.

Current Research Interests

  • Bioorganic Chemistry, Green Chemisrty, Medicinal Chemistry and Structural Biology
  1. Multinuclear and multidimensional NMR studies in solution of: a) the angiotensin converting enzyme (ACE) and synthetic polypeptide model compounds; b) Myelin Basic Protein Epitopes (MBP); c) Mapping of protein-ligand and ligand-receptor interactions through flexible docking calculations (implications to ACE and angiotensin II-AT1 receptor).
  2. Determination of the three dimensional structures of peptide hormones in solution by the use of NMR and molecular dynamics calculations-investigation of solvation-hydration phenomena of cis/trans amides, model peptides and peptide hormones-origin of cis isomer stabilization in proteins.
  3. Multidisciplinary approach for decoding the chemoprevention mechanism of biophenols from plant natural products: isolation, structure analysis and biological evaluation.
  4. Biocatalysis (Green Chemistry): Use of enzymes for biocatalytic transformations of natural products. Structural investigation using saturation transfer (STD) NMR, TR-NOESY and ‘in-cell’ NMR.
  5. Cleaning of wastewater systems and microalgae biomass to produce biofuels and biochemicals.

The binding of captopril trans conformation to the hACE (A) and Y 1096F mutant (B). The binding of captopril cis conformation to the hACE (C) and Y 1096F mutant (D). [A.G. Tzakos, N. Naqvi, K. Comporozors, R. Pierattelli, V. Theodorou, A. Husain* and I.P. Gerothanassis*, Biorg. Med. Chem. Lett. 16, 5084-5087 (2008)].

  1. 1H NMR spectrum of two quercetin derivatives with cells
  2. STD NMR of two quercetin derivatives with cells
  3. STD of mixture of two quercetin derivatives and a selective inhibitor of BCL-2 with the cells
  • NMR Structural Studies and Analytical Applications in Natural Products

                           Chemistry and Food Chemistry (http://nmrcenter.uoi.gr)

  1. Identification and quantitative evaluation of natural products in complex plant extracts by the use of high resolution one- and two- dimensional COSY, TOCSY, NOESY, ROESY, 1H–13C HSQC and HMBC NMR.
  2. Use of coupled methodologies of HPLC-SPE-NMR and CIDNP-NMR Spectroscopy.
  3. Simultaneous NMR identification and quantification of polyphenol compounds of plant extracts without isolation and derivatization steps.
  4. NMR studies of dairy products without chromatographic seperation. Use of NMR spin chromatographic techniques.

The first NMR direct and unequivocal identifica-tion of four geometric 18:2 conjugated linolenic acid isomers was achieved.

The sensitivity and resolution NMR barriers were overcome with selective suppression of the major NMR resonances and reduced 13C spectral width in the 1H–13C HSQC experiment.

The method is applicable in the lipid fraction of lyophilized milk and does not require further isolation or derivatization steps; it is selective, sensitive and has very good analytical characterri-stics. [C.G. Tsiafoulis, T. Skarlas, O. Tzamaloukas, D. Miltiadou and I.P. Gerothanassis, Anal. Chim. Acta, 821, 62-71 (2014)].

  • DFT Calculation of NMR Chemical Shifts-Beyond the Limits of X-ray and Νeutron Diffraction Μethods

1. Use of 1H NMR chemical shift calculations as a tool for investigating the nature of hydrogen bonding.

2. DFT calculations of 1H NMR chemical shifts for obtaining ultra high resolution structures.

[M.G. Siskos, M.I. Choudhary, A.G. Tzakos I.P. Gerothanassis*, Tetrahedron. 72, 8287-8293 (2016)].

Distinctions

  1. Honorary Research Fellow, QMW College, England, 1996
  2. Medal of the Ministry of Education of Ukraine, 2009.
  3. DSc, Univ. of East Anglia, 2011.
  4. June 2015-present: Adjunct Professor of International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan (UNESCO Research Center of Excellence).

Fellowships and Awards

  1. September 1977-July 1980: Greek Scholarship Foundation (University of East Anglia).
  2. March 1979: Price for the best MSc thesis submitted in Chemical Spectroscopy in the School of Chemical Sciences, University of East Anglia, England.
  3. July 1980-September 1980: NATO Research Fellowship (University of East Anglia, England)
  4. September 1980-June 1981: Research Postdoctorate Fellowship, Swiss Scientific Research Council (University of Lausanne, Switzerland).
  5. June 1984-August 1984: EMBO Short Term Fellowship (University of Lausanne,Switzerland)
  6. July 1985-September 1985: EMBO Short Term Fellowship (CNRS, Nancy, France).
  7. June 1986-August 1986: EMBO Short Term Fellowship (CNRS, Nancy, France).
  8. June 1987-September 1987: FEBS Short Term Fellowship (CNRS, Nancy, France).
  9. June 1988: EEC Short Term Fellowship (Inst. Curie, Orsay, France).
  10. July 1988-August 1988: EMBO Short Term Fellowship (CNRS, Nancy, France).
  11. July 1989-September 1989: DAAD Short Term Fellowship (Max Planck Institut, Mülheim, a.d. Ruhr, Germany).
  12. July 1990-August 1990: FEBS Short Term Fellowship (Max Planck Institut, Mülheim, a.d. Ruhr, Germany.
  13. November 1990-April 1991: Welcome Trust Fellowship (National Institute of Medical Research, London, England).
  14. Summer 1992, 1993, 1994: NATO Collaborative Grant, Institut Curie, Section de Biologie, Orsay, France.
  15. Summer 1995, 1996: EEC Grant, QMW College, London, England.
  16. Summer 1999, 2000, 2001: Collaborative Greece-Italy Program and NATO Grant, University of Florence, Italy.
  17. September 2011: Grant from the Greek Ministry of Education and DAAD (University of Leipzig, Germany)

Academic Administration

  1. Chairman of the Section of Organic Chemistry and Biochemistry, Dept. of Chemistry, UoI: 1997-1998, 1998-1999 and 1999-2000.
  2. Vice Chairman of the Dept. of Chemistry, UoI: 1999-2000.
  3. Chairman of the Dept. of Chemistry, UoI: 2000-2002 and 2002-2004.
  4. Chairman of the Dept. of Biological Applications & Technologies, UoI: 2004-2005.
  5. Chairman of the Dept. of Plastic Arts and Art Sciences, UoI: 2007-2010.
  6. Vice Rector of the UoI: 2003-2006.
  7. Rector of the UoI: 2006-2010.
  8. Chairman of the Dept. of Architecture Engineering, UoI: 2009-2010.
  9. Chairman of the Greek Rectors Conference 2010.

Administration in Quality Assurance in Higher Education

  1. Member of the Hellenic Quality Assurance and Accreditation Agency (HQAA) 2010-2014 (http://www.hqaa.gr) in the area of Natural Sciences (Mathematics, Physics, Chemistry, Material Science and Engineering Computer and Environmental Sciences).
  2. Member of the “National Committee of the Referencing process of the Hellenic National Qualifications Framework (HNQF) to the European Qualifications Framework (EQF)” 2013-2014.
  3. Vice Chairman of HQAA 2014 - present.

National Committees

  1. Chairman of the Committee of «Nanotechnology» in the frame of National Strategic Reference Framework (NSRF, 2007-2013) of the Greek General Secretariat for Research & Technology: 2008-2009.
  2. Chairman of the Committee of National Strategic Reference Framework (NSRF, 2007-2013) of the Greek Rectors Conference: 2007-2010.
  3. Chairman of the Committee of Physics-Chemistry-Materials of the Greek General Secretariat for Research & Technology: 2008-2009.
  4. Chairman of the Greek Supreme Chemistry Council: 2005 –2009.
  5. Member of the Greek National Committee for the “Institutional Framework for Research and Technology”, General Secretariat of Research & Technology, 2009.
  6. Member of the Greek National Plenary Council for Research & Technology: 2008-2009.
  7. Member of the Committee of the Greek Rectors Conference for the evaluation of the new Law for Research and Development, Greece, 2007.
  8. Chairman of the Committee for the application for the foundation of the Center for Research and Technology of Epirus, 2008.
  9. Coordination Committee of the Greek National Postdoctorate Program “PYTHAGORAS”, Greek Ministry of Education & Religious Affairs, 2005.
  10. Member of the evaluation Committee of the Greek National Postdoctorate Program “PYTHAGORAS”, Greek Ministry of Education & Religious Affairs, 2004.
  11. Member of the Evaluation Committee of the Greek National PhD Research Program “HERACLETOS” of the Greek Ministry of Education & Religious Affairs, 2003.
  12. Chairman of the Committee of the Core Research Centers and Laboratories of the UoI: 1999-2010.
  13. Chairman of the Committee of the Strategic Plan of the UoI: 1999, 2002, 2007 and 2008.
  14. Chairman of the NMR Center of the UoI, 1999-present.
  15. Member of the Evaluation Committee of Postgraduate Programs, Greek Ministry of Education & Religious Affairs, 1995.

International Committees

  1. National Representative of Greece in the European Community for “Site Issue Working Groups” (2009).
  2. National Representative of Greece in the Marie Curie Actions, European Communities, 2005-2006.
  3. Reviewer of the Commission of the European Communities, Directorate General for Science, Research and Development.

Reviewer

Reviewer of more than thirty (30) international journals, a representative list of which is provided below:

Analytica Chimica Acta, Chemical Biology, Chemical Physics Letters, European Journal of Biochemistry, FEBS Letters, Food Chemistry, Journal of Agricultural and Food Chemistry, Journal of the American Chemical Society, Journal of Chemical Education, Journal of Magnetic Resonance, Inorganic Chemistry, Journal of Organic Chemistry, Journal of Physical Chemistry, Journal of Saudi Chemical Society, Magnetic Resonance in Chemistry, Phytochemistry, etc.

Advisory Board

Member of Editorial Advisory Board of the Journals:

  1. “The Open Natural Products Journal”, Bentham Open, ISSN 1874-8481.
  2. “International Journal of Green Pharmacy”, Med Know.
  3. “ISRN Spectroscopy”, Hindawi Publishing Corporation.
  4. European Journal of Biophysics”, Science Publishing Group.

Author/Editor of Educational Books

  1. “Spectroscopy of Organic Compounds”. I.P. Gerothanassis, Greek Open University,
    pp. 1-122 (2000), in Greek.
  2. “Organic Chemistry”, vol 1-3, Morrison and Boyd, translation into Greek, three volumes with a total of 2000 printed pages, instructional material for basic and advanced courses in Organic Chemistry.

Author/Editor of Research Books

“Natural Antioxidant Phenols. Sources, Structure, Structure – Activity Relationship, Current Trends in Analysis and Characterization”. D. Boskou, I.P. Gerothanassis &
P. Kefalas (Eds), Research Signpost: Kerala, India, 2006.

Organization of International Conferences

  1. Member of the International Scientific Committee of the 14th Eurasia Conference on Chemical Sciences, Karachi, Pakistan (2016).
  2. Member of the International Scientific Committee of the 9th European Magnetic Resonance Conference, EUROMAR 2013, Crete, Greece (2013).
  3. Member of the National Organization Committee of “The Athens Dialogues”, International Conference on Culture and Civilization, Athens (2010).
  4. Organization and welcome address of the ASEA UNINET National Coordinator Meeting, UoI, June (2009).
  5. Member of the International Scientific Committee of the Sixth International Conference of the Chemical Societies of the South-Eastern European Countries, Bulgaria, September (2008).
  6. Member of the International Scientific Committee of Joint Greek-Italian Meeting on Chemistry of Biological Systems, Torino, Italy (1996).
  7. Member of the International Scientific Committee of NATO Advanced Study Institute on NMR of Biological Macromolecules - Proteins, Nucleic Acids, Polysaccharides, Crete, August (1993).

Lectures

Plenary/Invited Lectures in International Conferences of Educational Policy

9. “Degree Recognition in the new Era of Quality Assurance and Accreditation”, I.P. Gerothanassis, Greece Exploring Advanced Recognition in Higher Education – GEAR, Athens, Greece, 26 – 27 Arpil, 2017.

8. “European versus National Qualifications Frameworks in Higher Education Institutions: Ethical Framework and Evolution”, S.S. Pegka and I.P. Gerothanasssis, Fifth International Arab Conference on Quality Assurance in Higher Education (IACQA’2015), University of Sharjah-United Arab Emirates, 3-5/3/2015.

7. “National framework of Qualifications”, I.P. Gerothanassis, International Conference on Quality Assurance and Accreditation Agency (HQAA), Aristotle Univ. of Thessaloniki, Greece (2012). Representative of HQAA in the National Committee.

6. “Education, Research and Innovation”. I.P. Gerothanassis, Public Event entitled
‘30 years Euroelections’, Constantinos Karamanlis Institute for Democracy, Athens, Greece (2010).

5. “Research in Higher Education in Greece and the European Reality”. I.P. Gerothanassis, The University in the 21st Century: Challenges and Perspectives, International Conference, Karatzas Hall, Athens (2010).

4. “Education, Research and Innovation”. I.P. Gerothanassis, in III. Balkan Universities Network Meeting – Balkan Spring Educational Conference, Edrine, Turkey (2010).

3. “Presentation of the Hellenic Higher Education System”. I.P. Gerothanassis, National Representative delegated by the Greek Ministry of National Education and Religious Affairs, European Higher Education Fair, Beijing, China (2007).

2. “Presentation of the Hellenic Higher Education System”. I.P. Gerothanassis, National Representative delegated by the Greek Ministry of National Education and Religious Affairs, European Higher Education Fair, Bangkok, Thailand (2008).

1. “Attracting International Students”. I.P. Gerothanassis, Institute of International Network University Seminar “Internationalization of Higher Education in Europe: Opportunities and Challenges for Greece, Strategies and Policies”, Fulbright Foundation, Athens, Greece (2006).

Plenary Research Lectures in International Conferences

21. “Chemical analysis, monitoring of dynamic changes, metabolomics and “in cell” applications of NMR in natural products and food chemistry: Is the role of metrology underestimated?”, I.P. Gerothanasssis, International Workshop on Application of NMR in Pharmaceutics, Phytotherapeutics and Medicine, November 15-17, 2017, Istanbul, Turkey.

20. “NMR in Molecular Medicine and Drug Research: Three Selected Examples”, I.P. Gerothanasssis, 6th International Symposium-cum-Training Course on Molecular Medicine and Drug Research, November 6 - 9, 2017, 2017, Karachi, Pakistan.

19. “Chemical analysis, monitoring of dynamic changes, metabolomics and “in cell” applications of NMR in natural products and food chemistry: Is the role of metrology underestimated?” Ioannis P. Gerothanassis, rd IMEKOFOODS “Metrology Promoting Standardization and Harmonization in Food and Nutrition”, 1 – 4 .10.2017, KEDEA building, Thessaloniki, Greece.

18. “NMR in natural products: from chemical analysis and monitoring of dynamic changes to in cell NMR and structures beyond the limits of X-ray and neutron diffraction methods”, I.P. Gerothanasssis, 14th Eurasia Conference on Chemical Sciences, Karachi, Pakistan, December 15-18 (2016).

17. “NMR methodology developments in the analysis of complex mixtures of natural products: from metabolomics to in-cell NMR” 9th International Conference on "Instrumental Methods of Analysis-Modern Trends and Applications" (IMA) 2015, Kalamata, Greece, September (2015).

16. “Concepts and Applications of NMR”, I.P. Gerothanasssis, NASIC Workshop on Modern Spectroscopic Techniques and other Applications in Structure Determination, Karachi, Pakistan, December (2014).

15. “NMR Methodology Developments in the Analysis of Complex Mixtures of Natural Products: from Metabolomics to ‘in-cell’ NMR”, I.P. Gerothanasssis, 14th Asian Symposium on Medicinal Plants, Karachi, Pakistan, December (2013).

14. “NMR Methodology Developments in the Analysis of Complex Metabolite Mixtures”
8th International Conference on Instrumental Methods of Analysis: Modern Trends and Applications (IMA) 2013, Thessaloniki, Greece, September (2013).

13. “Novel NMR Applications to Phytochemical Analysis” I.P. Gerothanassis, COST Action FA 0906, Training School of Phytochemical Analysis, Thessaloniki, Greece, February (2013).

12. “Novel NMR Methods for the Demixing the Spectra of Complex Natural Extracts”. I.P. Gerothanassis, 13th International Symposium on Natural Products, Chemistry, Karachi, Pakistan, September (2012).

11. “NMR Studies of Antioxidants”. I.P. Gerothanassis, in 5th International Advanced Cource, Chemistry and Biochemistry of Antioxidants: Antioxidants in Health, Disease and Food Safety – Practical Assessment, Wageningen, Netherlands (2004).

10. “NMR Detection of Antioxidants”. I.P. Gerothanassis, in 4th International Advanced Course: Chemistry and Biochemistry of Antioxidants, Wageningen, Netherlands (2003).

9. “NMR Detection of Antioxidants”. I.P. Gerothanassis, in 3rd International Advanced Course: Chemistry and Biochemistry of Antioxidants, Wageningen, Netherlands (2002).

8. “NMR Detection of Antioxidants”. I.P. Gerothanassis, in 2nd International Advanced Course: Chemistry and Biochemistry of Antioxidants, Wageningen, Netherlands (2001).

7. “ΝΜR Detection of Antioxidants”. I.P. Gerothanassis, in 1st International Advance Course: Chemistry and Biochemistry of Antioxidants, Wageningen, Netherlands (2000).

6. “Multinuclear and Multidimensional NMR of Individual Peptide and Protein Bound Water in Solution and Solid State”. I.P. Gerothanassis, in Joint Greek-Italian Meeting on Chemistry of Biological Systems, Torino, Italy (1996).

5. “Fourier Transform IR and Multinuclear and Multidimensional NMR Spectroscopic Studies of Specific Peptide and Protein-Bound Water Molecules in Solution and Solid States”. I.P. Gerothanassis, in Joint Greek-Italian Meeting on Chemistry of Biological Systems and Molecular Chemical Engineering, UoI, Greece (1994).

4. “NMR Studies of Ligand-Protein Interactions Involving Quadrupolar Nuclei”. I.P. Gerothanassis, in NATO Advanced Study Institute on NMR of Biological Macromolecules - Proteins, Nucleic Acids, Polysaccharides, Crete, Greece (1993).

3. “Nuclear Shielding and Biomolecular Structure”. I.P. Gerothanassis, in NATO Advanced Study Institute on NMR of Biological Macromolecules - Proteins, Nucleic Acids, Polysaccharides, Crete, Greece (1993).

2. “Fourier Transform IR and Multinuclear and Multidimensional NMR Spectroscopic Studies of Specific Peptide and Protein-Bound Water Molecules”. I.P. Gerothanassis, in Fifth International Conference on the Spectroscopy of Biological Molecules, Loutraki, Greece (1993).

1. “17O NMR, Selective Observation of 1H–15N Protons and 1H–15N Multiple Quantum NMR as Novel Methods for Investigating Model Compounds of the Active Site of Hemoproteins”. I.P. Gerothanassis* and M. Momenteau, Greek-Italian Meeting on Chemistry of Biological System and Molecular Chemical Engineering, Loutraki (1990).

Invited Research Lectures in International Conferences

19.  “A Scientific Tour from Peptides and Proteins with the Late Paul Cordopatis to Natural Products”. Ioannis P. Gerothanassis and A.G. Tzakos, SEE-DRUG Conference – NMR applications in Life Sciences – Exploring Peptides & Proteins, Patras, Greece (18-20- June 2015)

18. “Novel NMR Methods for the Analysis of Crude Plant Extracts”. I.P. Gerothanassis,
P. Charisiadis, A. Primikyri, V. Kontogianni, C.G. Tsiafoulis, V. Exarchou, and A.G. Tzakos, International Conference for Health, Athens, Greece (2012).

17. “Plant Derived Bioactive Compounds: Isolation, Identification, Biological Evaluation and Enzymatic Modification of Lead Compounds”. I.P. Gerothanassis, 12th Euro-Asia Conference on Chemical Sciences EuAsC2S-12, Corfu, Greece (2012).

16. “Myelin Basic Protein: Structural Disorder, Protein Partners and Diseases”. I.P. Gerothanassis, in 5th International Greek Biotechnology Forum, Zappeio Megaro, Athens, Greece (2009).

15. “Structure – Function Discrimination, Domain Selective Ligand – Binding Model and the Role of Chloride Anions of Angiotensin I Converting Enzyme”. I.P. Gerothanassis, HALCHEM III, Ioannina, Greece (2006).

14. “Separation and Identification of the Major Constituents of Greek Hypericum Perforatum by LC – UV – Solid Phase Extraction NMR and LC-UV-MS/MS”. E.C. Tatsis, S. Boeren, V. Exarchou, A.N. Troganis, J. Vervoort, and I.P. Gerothanassis, in 4th Interna-tional Conference on Instrumental Methods of Analysis, Crete, Greece (2005).

13. “The Renin-Angiotensin System: NMR and Molecular Modeling Studies of Polypeptide Models of the Zn-active Site of the Angiotensin Converting Enzyme, Angiotensin II and Pοtential Analogues”. I.P. Gerothanassis, in 4th User Meeting of the European Large-Scale Facilities for NMR, Frankfurt, Germany (2001).

12. “Hydration Phenomena of Molecules of Biological Interest: Structural and Thermodynamic Aspects as Revealed by the Use of Multinuclear and Multidimensional NMR”. I.P. Gerothanassis, in 2nd International Conference of the Chemical Societies of the South-Eastern Countries, Chalkidiki, Greece (2000).

11. “Hydration Phenomena of Biomolecules in Solution and in the Solid as Revealed by the Triad: NMR-Structure-Thermodynamics”. I.P. Gerothanassis, XIX International Conference on Magnetic Resonance in Biological Systems, Florence, Italy (2000).

10.  “The Triad: NMR-Biomolecular Structure-Thermodynamics”. I.P. Gerothanassis, in
2nd Ηellenic Forum on Bioactive Peptides, Univ. of Patras, Greece (2000).

9. “NMR Methodology for the Analysis of Phenolic Acids in Complex Natural Mixtures”. V. Exarchou, I.P. Gerothanassis*, A. Troganis, M. Tsimidou and D. Boskou, in Instrumental Methods of Analysis: Modern Trends and Applications, Chalkidiki, Greece, (1999).

8. “Multinuclear (13C, 17O, 57Fe) NMR Studies of Heme Proteins and Synthetic Model Compounds”. I.P. Gerothanassis, in 5th International Symposium on Applied Bioinorganic Chemistry, Corfu, Greece (1999).

7. “Multinuclear (13C, 17O, 57Fe) NMR Studies of Heme Proteins and Synthetic Model Compounds”. I.P. Gerothanassis, 2nd User Meeting of the European Large-Scale Facilities for NMR, Woudschoten, The Netherlands (1998).

6. “Multinuclear NMR Studies in Proteins and Synthetic Model Compounds”. I.P. Gerothanassis and C.G. Kalodimos, in 1st International Conference of the Chemical Societies of the South-East European Countries-Chemical Sciences and Industry, Chalkidiki, Greece (1998).

5. “Multinuclear NMR Studies of the Fe–CO Unit in Hemoproteins and Synthetic Model Compounds in Solution and Solid States”. I.P. Gerothanassis, in 7th European Conference on the Spectroscopy of Biological Molecules, El Escorial, Spain (1997).

4. “Heteronuclear and Two-Dimensional NMR Studies of the Active Site of Hemoproteins and Synthetic Model Compounds in Solution and Solid States”. I.P. Gerothanassis, in XVIIth International Conference on Magnetic Resonance in Biological Systems, Keystone, Colorado, U.S.A. (1996).

3. “17O NMR and FTIR Studies of Haemoproteins and Synthetic Model Compounds in Solution and in the Solid State”. I.P. Gerothanassis* and M. Momenteau, in Fifth International Conference on the Spectroscopy of Biological Molecules, Loutraki, Greece (1993).

2. “17O NMR Studies of Hemoproteins and Synthetic Model Compounds in Solution and Solid States”. I.P. Gerothanassis, NMR Discussion Group, London (1993).

1. “17O NMR Studies of Oxygenated Hemoproteins and Synthetic Model Compounds”.
I.P. Gerothanassis* and M. Momenteau, Second International Symposium on Metal Ions in Biology and Medicine, Loutraki, Greece (1992).

Teaching Experience

Undergraduate Courses

Since 1983 up to present I have been teaching a variety of undergraduate courses including: (a) Introductory Courses in Organic Chemistry, (b) Organic Chemistry I, (c) Organic Chemistry II, (d) Organic Chemistry III, (e) Spectroscopy of Organic Compounds,

(f) Laboratory Organic Chemistry I and Laboratory of Organic Chemistry II as well as a variety of elective courses including Advanced Organic Chemistry Laboratory, Advanced Spectroscopy of Organic Compounds, Research Assay Diplome work.

Postgraduate Courses

Since 1994 up to present I have been teaching a variety of postgraduate courses including:

(a) Advanced Courses of Organic Chemistry, (b) Advanced Courses of Spectroscopy in Organic Compounds, (c) Advanced Courses of NMR Spectroscopy and (d) Laboratory of Advanced Spectroscopic Techniques.

Research Group

Supervision of PhD and MSc Students

Thirteen (13) PhD students have completed their thesis under my supervision (the number of publications denote the respective number of my CV)

  1. Dr. C. Vakka (1997), publications 74, 75, 81, 82, 88
  2. Dr. C. Kalodimos (1998), publications 54, 57, 58, 63, 64, 65, 66, 73, 76
  3. Dr. V. Exarchou (2001), publications 44, 45, 51, 61
  4. Dr. A. Tzakos (2006), publications 30, 34, 36, 39, 40, 42, 43
  5. Dr. K. Tsanaktsidis (2006), publications 41, 77, 85
  6. Dr. E. Tatsis (2008), publications 25, 27, 47
  7. Dr. C. Barbarosou (2007), publication 31
  8. Dr. I. Leaondari (2008), publication 26
  9. Dr. V. Goulas (2009), publications 1, 13, 20, 24
  10. Dr. V. Kontogianni (2009), publications 14, 23
  11. Dr. A.A. Nerantzaki (2010), publication 17
  12. Dr. P. Charisiadis (2012), publications 5, 10, 15, 19
  13. Dr. A. Primikyri (2013), publications 8, 12

Eight (8) MSc students have completed their thesis under my supervision.

Six (6) of my former PhD students followed an academic/research career:

  1. Kalodimos, C. <babis@rutgers.edu>, Professor, Dept. of Chemistry & Chemical Biology, Rutgers University, USA.
  2. Tzakos, A. <atzakos@cc.uoi.gr>, As. Professor, Dept. of Chemistry, University of Ioannina, Greece.
  3. Tsanaktsidis, K. <tsanaktsidis@kozani.teikoz.gr>, Professor, Technical Institution of West Macedonia, Greece.
  4.   Goulas, V. <vlasios.goulas@cut.ac.cy>, Specific Scientist, Dept. of Agricultural Sciences, Biotechnology &  Food Sciences, Cyprus Univ. of Technology, Cyprus.
  5.   Exarchou, V. <vexarc@cc.uoi.gr>, Specific Research and Teaching Scientist, UoI.
  6.   Tatsis, E. <evangelos.tatsis@jic.ac.uk > Researcher, John Innes Center, UK.

Postdoctorate Collaborators

Ten post doctorate research associates carried out research activities under my supervision.

Current Research Group at the University of Ioannina

  1. Dr. Tsiafoulis, C., Specific technical-administrative staff
  2. Dr. Kontogianni, V.G., Post doctorate researcher
  3. Dr. Primikyri A., Post doctorate researcher
  4. Dr. Skarlas, T., MSc student
  5. Alexandri E., MSc student
  6. Venianakis, Th., MSc student
  7. Stambouli, O., MSc student

Current Research Group at the International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry), University of Karachi, Pakistan

  1. Prof. Iqbal M. Choudhary, Director
  2. Dr. Atia-tul-Wahab, As. Professor, Ph. D. (University of Karachi)
  3. Dr. Hina Siddiqui, As. Professor, Coordinator, ICCBS Alumni Club, H.E.J. Research Institute of Chemistry
  4. Mr. Raheel Ahmed, PhD student
  5. Mrs. Saima Hassan Mari, PhD student
  6. Mrs. Aneela Fayaz, PhD student

Academic Research Collaborators

Cyprus

Manganaris, G. <george.manganaris@cut.ac.cy>, As. Professor, Dept. of Agricultural Sciences, Biotechnology & Food Sciences, Cyprus Univ. of Technology

Miltiadou, D. <despoina.miltiadou@cut.ac.cy>, Lecturer, Dept. of Agricultural Sciences, Biotechnology & Food Sciences, Cyprus Univ. of Technology

Tzamaloukas, O. <ouranios.tzamaloukas@cut.ac.cy>, Specific Scientist, Dept. of Agricultural Sciences, Biotechnology & Food Sciences, Cyprus Univ. of Technology

Germany

Giannis, A. <giannis@uni-leipzig.de>, Professor, Inst. for Organic Chemistry, Univ. of Leipzig

Greece

Fotsis, T. <thfotsis@uoi.gr>, Professor of Medical School, UoI

Galaris, D. <dgalaris@uoi.gr>, Professor of Medical School, UoI

Lamari, F. <F.Lamari@upatras.gr>, As. Professor, Dept. of Pharmacology, Univ. of Patras

Lekka, C. <chlekka@cc.uoi.gr>, As. Professor, Dept. of Material Sciences Engineering, UoI

Matsoukas, I. <imats@upatras.gr>, Professor, Dept. of Chemistry, Univ. of Patras

Siskos, M. <msiskos@cc.uoi.gr>, As. Professor, Dept. of Chemistry, UoI

Theodorou, V. <vtheodor@cc.uoi.gr>, As. Professor, Dept. of Chemistry, UoI

Tselepis, A. <atselep@uoi.gr>, Professor, Dept. of Chemistry, UoI

Tsimidou, M. <tsimidou@chem.auth.gr>, Professor, Dept. of Chemistry, AUTh

Italy

Luchinat, C. <luchinat@cerm.unifi.it>, Professor, CERM, Univ. of Florence

Russo, N. <nino.russo@unical.it>, Professor, Dept. of Chemistry, Univ. of Calabria

Pakistan

Choudhary, I.M. <iqbal.choudhary@iccs.edu>, Professor, Director of International Center for Chemical & Biological Sciences Univ. of Karachi

Serbia

Stojanovic, I. <ivana@ibiss.bg.ac.rs>, Professor, Dept. of Immunology, Institute for Biological Research ‘Sinisa Stankovic’, Univ. of Belgrade

Research Collaborations with Industries and non Academic Institutions (in the last 5 years)

3073 in international literature (Web of Science), without self-citations 2499, h-index 30

Research Publications

Publications in International Journals

One hundred fifty (150) publications, with a total impact factor of the journals of ~527and average impact factor per journal of ~3.5. The titles, the authors and the journals of the publications are listed below (*denotes the author to whom correspondence should be addressed)

150. “Enriching the biological space of natural products, through real time biotransformation monitoring: the NMR tube bioreactor”. A. Chatzikonstantinou, M. Chatziathanasiadou, E. Ravera, M. Fragai, G. Parigi, I. Gerothanassis; C. Luchinat, H. Stamatis, A. Tzakos*, BBA - General Subjects, 1862, 1-8 (2018).

149.  “High Resolution NMR Spectroscopy as a Structural and Analytical Tool of Unsaturated Lipids in Solution”. E. Alexandri, R. Ahmed, H. Sidiqui, M.I. Choudhary, C.G. Tsiafoulis, I.P. Gerothanassis*, Molecules, 22, 1663 doi:10.3390/molecules22101663 (2017).

148. “Selective 1D TOCSY NMR method for the determination of glutathione in white wine”. V.G. Kontogianni, C.G. Tsiafoulis, I.G. Roussis, I.P. Gerothanassis* Anal. Methods 9, 4464-4470 (2017) UoI.

147. “Refinement of labile hydrogen position of enol-enol tautomers of β-dicarbonyl compounds based on DFT calculations of 1H NMR chemical shifts in solution: comparison with X-Ray and neutron diffraction methods”. M.G. Siskos, M. Iqbal Choudhary and I.P. Gerothanassis* Org. Biomol. Chem. 15, 4655-4666 (2017). UoI.

146. “Hydrogen Atomic Positions of O–H···O Hydrogen Bonds in Solution and in the Solid State: The Synergy of Quantum Chemical Calculations with 1H-NMR Chemical Shifts and X-ray Diffraction Methods”. M.G. Siskos*, M. Iqbal Choudhary and I.P. Gerothanassis* Molecules 22(3), 415 (2017). UoI.

145. “Determination of polyphenolic phytochemicals using highly deshielded –OH 1H-NMR signals”. P. Charisiadis, V.G. Kontogianni, C.G. Tsiafoulis, A.G. Tzakos and I.P. Gerothanassis* Phytochem. Anal. 28(3), 159-170 (2017). UoI.

144. “1H ΝΜR chemical shift assignment, structure and conformational elucidation of hypericin with the use of DFT calculations – The challenge of accurate positions of labile hydrogens”.  M.G. Siskos*, M. Iqbal Choudhary, A.G. Tzakos and I.P. Gerothanassis* Tetrahedron 72, 8287-8293 (2016). UoI.

143. “PRESS: protein S-sulfenylation server”. M. Sakka, G. Tzortzis, M.D. Mantzaris, N. Bekas, T. F. Kellici, A. Likas, D. Galaris, I. P. Gerothanassis and A.G. Tzakos*. Bioinformatics 32, 2710-2712 (2016). UoI.

142. “Deconvoluting the dual Antiplatelet activity of a plant extract”. V.G. Kontogianni, M.E. Tsoumani, T.F. Kellici, T. Mavromoustakos, I.P. Gerothanassis, A.D. Tselepis, and A.G. Tzakos*. J. Agric. Food Chem. 64, 4511-4521 (2016). UoI.

141. “Ethyl Acetate Extract of Origanum vulgare L. ssp. hirtum Prevents Streptozotocin-Induced Diabetes in C57BL/6 Mice”. Μ. Vujicic, Ι. Nikolic, V.G. Kontogianni, T. Saksida, P. Charisiadis, B. Vasic, S. Stosic-Grujicic, I.P. Gerothanassis, A.G. Tzakos and Stojanovic I.* J. Food Sci. 81, 846-853 (2016). UoI.

140. “Leveraging NMR and X-ray data of the free ligands to build better drugs targeting Angiotensin II type 1 G-Protein coupled receptor”. Kellici TF, Ntountaniotis D, Kritsi E, Zervou M, Zoumpoulakis P, Potamitis C, Durdagi S, Salmas RE, Ergun G, Gokdemir E, Halabalaki M, Gerothanassis IP, Liapakis G.*, Tzakos A*, Mavromoustakos, T.* Curr. Med. Chem. 23, 36-59 (2016). UoI.

139. “1H NMR metabolic fingerprinting to probe temporal postharvest changes on qualitative attributes and phytochemical profile of sweet cherry fruit”. V. Goulas, I.S. Minas, P. Kourdoulas, A. Lazaridou, A. Molassiotis, I.P. Gerothanassis and G.A. Manganaris*. Front. Plant. Sci. 6, 36-59 (2015). UoI.

138. “Beyond traditional balsamic vinegar: Compositional and sensorial characteristics of industrial balsamic vinegars and regulatory requirements”. S. Lalou, E. Hatzidimitriou, M. Papadopoulou, V.G. Kontogianni, C.G. Tsiafoulis, I.P. Gerothanassis and M.Z. Tsimidou*. J. Food Comp. Anal. 43, 175-184 (2015). UoI.

137. “Accurate ab initio calculations of O–H⋯O and O–H⋯-O proton chemical shifts: towards elucidation of the nature of the hydrogen bond and prediction of hydrogen bond distances”. M.G. Siskos*, A.G. Tzakos and I.P. Gerothanassis*. Org. Biomol. Chem. 13, 8852-8868 (2015). UoI.

136. “Selective 1D TOCSY NMR Experiments for a Rapid Identification of Minor Components in the Lipid Fraction of Milk and Dairy Products: Towards Spin-Chromatography?”. C. Papaemmanouil, C.G. Tsiafoulis*, D. Alivertis, O. Tzamaloukas, D. Miltiadou, A. Tzakos and I.P. Gerothanassis*. J. Agric Food. Chem. 63, 5381-5387 (2015). UoI.

135. “Understanding Zinc (II) Chelation with Quercetin and Luteolin: A Combined NMR and Theoretical Study”. A. Primikyri, G. Mazzone*, C. Lekka, A.G. Tzakos, N. Russo and I.P. Gerothanssis*, J. Phys. Chem. B 119, 83-95 (2015). UoI.

134. “1H-NMR as a Structural and Analytical Tool of Intra- and Intermolecular Hydrogen Bonds of Phenol-Containing Natural Products and Model Compounds”. P. Charisiadis, V. Kontogianni, C.G. Tsiafoulis, A.G. Tzakos, M. Siskos and I.P. Gerothanassis*, Molecules, 19, 13643-13682 (2014). UoI.

133. “Dynamic Changes in Composition of Extracts of Natural Products as Monitored by in Situ NMR”. P. Charisiadis, C.G. Tsiafoulis, A.G. Tzakos and I.P. Gerothanassis*, Magn. Reson. Chem., 52, 764-768 (2014). UoI.

132. “Synthetic Methodologies in Organic Chemistry Involving Incorporation of 17O and 18O Isotopes”. V. Theodorou*, K. Skobridis, D. Alivertis and I.P. Gerothanassis. J. Label. Compd. Radiopharm. 57, 481-508 (2014). UoI.

131. Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II”. F. Magnani, C.G. Pappas, T. Crook, V. Magafa, P. Cordopatis, S. Ishiguro, N. Ohta, J. Selent, S. Bosnyak, E.S. Jones, I.P. Gerothanassis, M. Tamura, R.E. Widdop and A.G Tzakos*. ACS Chem. Biol. 9, 1420-1425 (2014). UoI.

130. “Direct Binding of Bcl-2 Family Proteins by Quercetin Triggers Its Pro-Apoptotic Activity”. A. Primikyri, M.V. Chatziathanasiadou, E. Karali, E. Kostaras, M. D. Mantzaris, E. Hatzimichael, J.-S. Shin, S.-W. Chi, E. Briasoulis, E. Kolettas, I.P. Gerothanassis*, and A.G. Tzakos*, ACS Chem. Biol. 9, 2737-2741 (2014). UoI.

129.“Direct Nuclear Magnetic Resonance Identification and Quantification of Geometric Isomers of Conjugated Linoleic Acid in Milk Lipid Fraction without Derivatization Steps: Overcoming Sensitivity and Resolution Barriers”, C.G. Tsiafoulis, T. Skarlas, O. Tzamaloukas, D. Miltiadou and I.P. Gerothanassis*, Anal. Chim. Acta 821, 62-71 (2014). UoI.

128.“A Novel NMR Method for the Determination and Monitoring of Evolution of Hydrogen Peroxide in Aqueous Solutions”, C. Tsiafoulis* and I.P. Gerothanassis*, Anal. Bioanal. Chem., 406, 3371-3375 (2014). UoI.

127. “Evaluation of the Phytochemical Content, Antioxidant Activity and Antimicrobial Properties of Mountain Tea (Sideritis syriaca) Decoction”, V. Goulas*, V. Exarchou*, L. Kanetis, I.P. Gerothanassis, J. Funct. Foods 6, 248-258 (2014). UoI.

126. “Olive Leaf Extracts are a Natural Source of Advanced Glycation End Product Inhibitors”. V.G. Kontogianni*, P. Charisiadis, E. Margianni, F.N. Lamari, I.P. Gerothanassis, and A.G. Tzakos* J. Med. Food 16, 817-822 (2013). UoI.

125.“Investigation of Solute-Solvent Interactions in Phenol Compounds: Accurate Ab Initio Calculations of Solvent Effects on 1H NMR Shieldings”. M. Siskos*, V.G. Kontogianni, C. Tsiafoulis, A. Tzakos, and I.P. Gerothanassis*, Org. Biomol. Chem. 11, 7400-7411 (2013). UoI.

124. “Phytochemical Composition of ‘Mountain Tea’ from Sideritis Clandestina subsp. Chandestina and Evaluation of its Behavioral and Oxidant/Antioxidant Effects on Adult Mice”. C.G. Vasilopoulou, V.G. Kontogianni, Z.I. Linardaki, G. Iatrou, F.N. Lamari, A.A. Nerantzaki, I.P. Gerothanassis, A.G. Tzakos* and M. Margarity*, Eur. J. Nutr. 52, 107-116 (2013). UoI.

123. “Ηydrogen Bonding Probes of Phenol ‒OH Groups”. V. Kontogianni, A. Primikyri, V. Exarchou, P. Charisiadis, A. Tzakos, I.P. Gerothanassis*, Org. Biomol. Chem. 11, 1013-1025 (2013). UoI.

122. “Phytochemical Profile of Rosmarinus Officinalis and Salvia Officinalis Extracts and Correlation to their Antioxidant and Anti-proliferative Activity”. V.G. Kontogianni*, G. Tomic, I. Nikolic, A.A. Nerantzaki, N. Sayyad, S. Stosic-Grujicic, I. Stojanovic*, I.P. Gerothanassis, A.G. Tzakos*, Food Chem. 136, 120-129 (2013). UoI.

121. “Classification, Biotransformation and Antioxidant Activity of Olive Fruit Biophenols: A Review”. V. Goulas*, P. Charisiadis, I.P. Gerothanassis and G.A. Manganaris, Current Bioactive Compounds 8, 232-239 (2012). UoI.

120. “Fine - Tunning of the the Difussion Dimension of –OH Groups for High Resolution DOSY NMR Applications in Grude Enzymatic Transformations and Mixtures of Organic Compounds”. A. Primikyri, E. Kyriakou, P. Charisiadis, C. Tsiafoulis, H. Stamatis, A.G. Tzakos* and I.P. Gerothanassis*, Tetrahedron 68, 6887-6891 (2012). UoI.

119. “On the Hydration State of Amino Acids and their Derivatives at Different Ionization States: A Comparative Multinuclear NMR and Crystallographic Investigation”. C. Papas, A.G. Tzakos and I.P. Gerothanassis*, Journal of Amino Acids vol. 2012, ID 565404 (2012) doi: 10.1155/2012/565404. UoI.

118. "Rapid and Direct Low Micromolar NMR Method for the Simultaneous Detection of Hydrogen Peroxide and Phenolics in Plant Extracts”. P. Charisiadis, C.G. Tsiafoulis, V. Exarchou, A.G. Tzakos and I.P. Gerothanassis*, J. Agric. Food Chem. 60, 4508-4513 (2012). UoI.

117.“Recognition Pliability is Coupled to Structural Heterogeneity: A Calmodulin Intrinsically Disordered Binding Region Complex”. M. Nagulapalli. G. Parigi, J. Yuan, J. Gsponer, G. Deraos, V.V. Bamm, G. Harauz, J. Matsoukas, M.R.R. de Planque, I.P. Gerothanassis, M.M. Babu, C. Luchinat* and A.G. Tzakos*, Structure, 20, 522-533 (2012). UoI.

116. "Unexpected Enzyme-Catalyzed Regioselective Acylation of Flavonoid Aglycones and Rapid Product Screening”. E. Kyriakou, A. Primikyri, P. Charisiadis, M. Katsoura, I.P. Gerothanassis, H. Stamatis and A.G. Tzakos*, Org. Biomol. Chem. 10, 1739-1742 (2012). UoI.

115. “Exploring the Antioxidant Potential of Teucrium Polium Extracts by HPLC-SPE-NMR and On-Line Radical-Scavenging Activity Detection”. V. Goulas, A.M. Gomez-Caravaca, V. Exarchou*, I.P. Gerothanassis, A. Segura-Carretero and A. Fernandez Gutierrez, LWT-Food Science and Technology 46, 104-109 (2012). UoI.

114. “Phenolic Compounds and Antioxidant Activity of Olive Leaf Extracts” V.G. Kontogianni* and I.P. Gerothanassis, Nat. Prod. Res. 26, 186-189 (2012). UoI.

113. “Unprecedented Ultra-high-resolution Hydroxy Group 1H NMR Spectroscopic Analysis of Plant Extracts”. P. Charisiadis, A. Primikyri, V. Exarchou, A. Tzakos and I.P. Gerothanassis*, J. Nat. Prod. 74, 2462-2466 (2011). UoI.

112. “Oxygen-17 NMR”. I.P. Gerothanassis, in Encyclopedia of Nuclear Magnetic Resonance (D.M. Grant and R.K. Harris eds.), Wiley, Baffins Lane, Chichester (2011).

111. “Novel Determination of the Total Phenolic Contents in Crude Plant Extracts by the Use of 1H NMR of the ‒OH Spectral Region”. A.A. Neratzaki, C.G. Tsiafoulis*, P. Charisiadis, V.G. Kontogianni and I.P. Gerothanassis*, Anal. Chim. Acta, 688, 54-60 (2011). .

110. “A New Method for the Determination of Free L-carnitine in Serum Samples Based on High Field Single Quantum Coherence Filtering 1H‒NMR Spectroscopy”. C.G. Tsiafoulis, V. Exarchou, P.P. Tziova, E. Bairaktari, I.P. Gerothanassis and A.N. Troganis*, Anal. Bioanal. Chem. 399, 2285-2294 (2011). UoI.

109. “Exploring the “Forgotten”- OH NMR Spectral Region in Natural Products”. P. Charisiadis, V. Exarchou, A.N. Troganis and I.P. Gerothanassis*, Chem. Commun. 46, 3589-3591 (2010). UoI.

108.  “Contribution of Flavonoids to the Overall Radical Scavenging Activity of Olive (Olea Europea L.) Leaf Polar Extracts”. V. Goulas, V.T. Papoti, V. Exarchou, M.Z. Tsimidou* and I.P. Gerothanassis* J. Agric. Food Chem. 58, 3303-3308 (2010). UoI.

107. “Oxygen-17 NMR Spectroscopy: Basic Principles and Applications (Part II)”. I.P. Gerothanassis, Progr. NMR Spectrosc. 57, 1-110 (2010). UoI.

106. “Oxygen-17 NMR Spectroscopy: Basic Principles and Applications (Part I)”. I.P. Gerothanassis, Progr. NMR Spectrosc. 56, 95-197 (2010). UoI.

105. “Rapid and Novel Discrimination and Quantification of Oleanolic and Ursolic Acids in Complex Plant Extracts using Two-Dimensional Nuclear Magnetic Resonance Spectroscopy-Comparison with HPLC Methods”. V.G. Kontogianni, V. Exarchou, A. Troganis and I.P. Gerothanassis*, Anal. Chim. Acta 635, 188-195 (2009). UoI.

104. “Phytochemicals in Olive-Leaf Extracts and their Antiproliferative Activity against Cancer and Endothelial Cells”. V. Goulas, V. Exarchou, A.N. Troganis, E. Psomiadou, T. Fotsis, E. Briasoulis and I.P. Gerothanassis*, Mol. Nutr. & Food Res. 53, 600-608 (2009). UoI.

103. “1H‒NMR Determination of Hypericin and Pseudohypericin in Complex Natural Mixtures by the Use of Strongly Deshielded OH Groups”. E. Tatsis, V. Exarchou, A. Troganis and I.P. Gerothanassis*, Anal. Chim. Acta, 607, 219-226 (2008). UoI.

102. “A Structural Characterization of Human SCO2”. L. Banci, I. Bertini*, S. Ciofi-Baffoni, I.P. Gerothanassis, I. Leontari, M. Martinelli and S. Wang, Structure 15, 1132-1140 (2007). UoI.

101. “Identification of the Major Constituents of Hypericum Perforatum by LC/SPE/NMR and/or LC/MS”. E.C. Tatsis, S. Boeren, V. Exarchou, A.N. Troganis, J. Vervoort and I.P. Gerothanassis*, Phytochemistry 68, 383-393 (2007). UoI.

100. “Hyphenated Liquid Chromatography / Nuclear Magnetic Resonance Techniques”. V. Exarchou, I.P. Gerothanassis, J. Vervoort and T.A. van Beek, Natural Antioxidant Phenols. Sources, Structure – Activity Relationship, Current Trends in Analysis and Characterization. D. Boskou, I.P. Gerothanassis, P. Kefalas, (Eds.). Research Signpost: Kerala, India, 2006, Chapter 6, p. 143-156. UoI.

 99. “NMR Studies of Antioxidant Plant Phenols: Basic Parameters and Methodologies”. V. Exarchou and I.P. Gerothanassis, Natural Antioxidant Phenols. Sources, Structure – Activity Relationship, Current Trends in Analysis and Characterization. D. Boskou, I.P. Gerothanassis, P. Kefalas, (Eds.). Research Signpost: Kerala, India, 2006, Chapter 5, p. 125-142. UoI.

 98. “The Molecular Basis for the Selection of Captopril cis and trans Conformations by Angiotensin I Converting Enzyme”. A.G. Tzakos, N. Naqvi, K. Comporozos, R. Pierattelli, V. Theodorou, A. Husain* and I.P. Gerothanassis*, Bioorg. Med. Chem. Lett., 16, 5084-5087 (2006). UoI.

 97. “Solvation Properties of N-Substituted Cis and Trans Amides are not Identical: Significant Enthalpy and Entropy Changes are Revealed by the Use of Variable Temperature 1H NMR in Aqueous and Chloroform Solutions and Ab Initio Calculations”. A. Troganis, E. Sicilia, K. Barbarossou, I.P. Gerothanassis* and N. Russo*, J. Phys. Chem. A. 109, 11878-11884 (2005). UoI.

 96. “LC-NMR Coupling Technology: Recent Advancements and Applications in Natural Products Analysis”. V. Exarchou*, M. Krucker, T.A. Van Beek, J. Vervoort, I.P. Gerothanassis and K. Albert, Magn. Reson. Chem., 43, 681-687 (2005) invited article. UoI.

 95. “Structure and Function of the Myelin Proteins: Current Status and Perspectives in Relation to Multiple Sclerosis”. A.G. Tzakos, P. Kursula, V. Theodorou, A. Troganis, T. Tselios, C. Svarnas, J. Matsoukas, V. Apostolopoulos and I.P. Gerothanassis, Current Med. Chem. 12, 1569-1587 (2005). UoI.

 94. “Domain-Selective Ligand-Binding Modes and Atomic Level Pharmacophore Refinement in Angiotensin I Converting Enzyme (ACE) Inhibitors”. A.G. Tzakos and I.P. Gerothanassis*, Chem. Biol. Chem. 6, 1089-1103 (2005). UoI.

 93. “NMR and Molecular Dynamics Studies of an Autoimmune Myelin Basic Protein Peptide and its Antagonist. Structural Implications for the MHC II (1-Au) – Peptide Complex from Docking Calculations”. A.G. Tzakos, P. Fuchs, N.A.J. van Nuland, A. Troganis, T. Tselios, S. Deraos,  J. Matsoukas, I.P. Gerothanassis* and A.M.J.J. Bonvin, Eur. J. Biochem. 271, 3399-3413 (2004). UoI.

 92. “On the Structural Basis of the Hypertensive Properties of Angiotensin II: A Solved Mystery or a Controversial Issue?”. A.G. Tzakos, A. Troganis and I.P. Gerothanassis*, Current Topics in Medicinal Chemistry, 4, 431-444 (2004). UoI.

 91. “On the Detection of Both Carbonyl and Hydroxyl Oxygens in Amino Acid Derivatives: A 17O NMR Reinvestigation”. V. Theodorou, A.N. Troganis and I.P. Gerothanassis*, Tetrahedron Letters, 45, 2243-2245 (2004). UoI.

 90. “LC-UV-Solid Phase Extraction-NMR-MS Combined with a Cryogenic Flow Probe and its Application to the Identification of Compounds Present in Greek Oregano”. V. Exarchou*, M. Godejohann, T.A. Van Beek, I.P. Gerothanassis and J. Vervoort, Anal. Chem. 75 6288-6294 (2003). UoI.

 89. “Structure-Function Discrimination of the N‒ and the C‒ Catalytic Domains of Human Angiotensin-Converting Enzyme: Implications for Cl- Activation and Peptide Hydrolysis Mechanisms”. A. Tzakos, A.S. Galanis, G.A. Spyroulias, P. Cordopatis, E.M. Zoupa and I.P. Gerothanassis*, Protein Engin. 16, 993-1003 (2003). UoI.

 88. “On the Molecular Basis of the Recognition of Angiotensin II (AII). NMR Structure of AII in Solution Compared with the X-ray Structure of AII Βound to the mAb Fab131”. A.G. Tzakos, A.M.J.J. Bonvin, A. Troganis, P. Cordopatis, M.L. Amzel, I.P. Gerothanassis* and N.A.J. van Nuland, Eur. J. Biochem., 270, 849-860 (2003). UoI.

 87. “14N NMR Relaxation Times of Several Protein Amino Acids in Aqueous Solution-Comparison with 17O NMR Data and Estimation of the Relative Hydration Numbers in the Cationic and Zwitterionic Forms”. A.N. Troganis*, C. Tsanaktsidis and I.P. Gerothanassis, J. Magn. Reson. 164, 294-303 (2003). UoI.

 86. “Comparison of the Solution Structures of Angiotensin I & II. Implication for Structure-Function Relationship”. G.A. Spyroulias*, P. Nikolakopoulou, A. Tzakos, I.P. Gerothanassis, V. Magafa, E. Manessi-Zoupa, and P. Cordopatis, Eur. J. Biochem., 270, 2163-2173 (2003). UoI.

 85. “Zinc Binding in Peptide Models of Angiotensin-I Converting Enzyme Active Sites Studied Through 1H–NMR and Chemical Shift Perturbation Mapping”. A. Galanis, G. Spyroulias*, R. Pierattelli, A. Tzakos, A. Troganis, I.P. Gerothanassis, G. Pairas,
E. Manessi-Zoupa and P. Cordopatis, Biopolymers 69, 244-252 (2003). UoI.

 84. “Do Strong Intramolecular Hydrogen Bonds Persist in Aqueous Solution? Variable Temperature Gradient 1H, 1H–13C GE-HSQC and GE-HMBC NMR Studies of Flavonols and Flavones in Organic and Aqueous Mixtures”. V. Exarchou, A. Troganis, I.P. Gerothanassis*, M. Tsimidou and D. Boskou, Tetrahedron, 58, 7423-7429 (2002). UoI.

 83. “Antioxidant Activities and Phenolic Composition of Extracts from Greek Oregano, Greek Sage and Summer Savory”. V. Exarchou, N. Nenadis, M. Tsimidou*, I.P. Gerothanassis, A. Troganis and D. Boskou, J. Agric. Food Chem., 50, 5294-5299 (2002). UoI.

*82.     “Nuclear Magnetic Resonance (NMR) Spectroscopy: Basic Principles and Phenomena, and their Applications to Chemistry, Biology and Medicine”. I.P. Gerothanassis*,
A. Troganis*, V. Exarchou and K. Barbarossou, Chem. Educ.: Research & Practice in Europe, 3, 229-252 (2002). UoI.

 81. “Towards a Consensus Structure of Hypericin in Solution: Direct Evidence for a single Tautomer and Different Ionization States in Protic and Nonprotic Solvents by the Use of Variable Temperature Gradient 1H NMR”. D. Skalkos, E. Tatsis, I.P. Gerothanassis* and A. Troganis, Tetrahedron, 58, 4925-4929 (2002). UoI.

 80. High Nuclearity ZnII/Me (C5NH4)2 Clusters by “Depolymerization”: Conversion of a Three-Dimensional Coordination Polymer Containing Hexameric Units into its Constituent Hexanuclear Complex”. N. Lalioti, C.P. Raptopoulou, A. Terzis, A.E. Aliev, I.P. Gerothanassis, E. Manessi-Zoupa and S.P. Perlepes, Angew. Chem. Int. Ed., 40, 3211-3214 (2001). UoI.

 79. “The 17O‒NMR Shielding Range and Shielding Time Scale and Detection of Discrete Hydrogen-Bonded Conformational States in Peptides”. Ι.P. Gerothanassis, Biopolymers, 59, 125-130 (2001). UoI.

 78. “Natural Abundance 15N CP MAS NMR as a Novel Tool for Investigating Metal Binding to Nucleotides in the Solid State”. K. Barbarossou, A. E. Aliev, I.P. Gerothanassis*, J. Anastassopoulou* and T. Theophanides, Inorg. Chem., 40, 3626-3628(2001). UoI.

 77. “Analysis of Phenolic Acids in Complex Phenolic Mixtures by the Use of Variable Temperature Two Dimensional 1H‒1H COSY, 1H‒13C HMQC and 1H‒13C HMBC Gradient Enhanced NMR Spectroscopy: Application to Methanolic Extracts of Several Oregano Species”. V. Exarchou, A. Troganis, I.P. Gerothanassis*, M. Tsimidou and D. Boskou, J. Agric. Food Chem., 49, 2-8 (2001). UoI.

 76. “Treatment of Experimental Allergic Encephalomyelitis (EAE) by a Rationally Designed Cyclic Analogue of Myelin Basic Protein (MBP) Epitope 72-85”. T. Tselios, I. Daliani, S. Deraos, S. Thymianou, E. Matsoukas, A. Troganis, I.P. Gerothanassis, A. Mouzaki, T. Mavromoustakos, L. Probert and J. Matsoukas*, Bioorg. Med. Chem. Lett., 10, 2713-2717 (2000). UoI.

 75. “Density Functional Study of a Model Amide. Prediction of Formamide Geometry, Dipole Moment, IR Harmonic Vibration νC=O and GIAO NMR Shieldings”. T. Kupka*, I.P. Gerothanassis and I.N. Demetropoulos, THEO CHEM, 531, 143-157 (2000). UoI.

 74. “Multinuclear (13C, 17O, 57Fe) NMR Studies of Carbonmonoxy Heme Proteins and Synthetic Model Compounds”. C.G. Kalodimos, I.P. Gerothanassis*, R. Pierattelli and A. Troganis, J. Inorg. Biochem., 79, 371-380 (2000). UoI.

 73. “Thermodynamic Origin of Cis/Trans Isomers of a Proline-Containing β-turn Model Dipeptide in Aqueous Solution: A Combined Variable Temperature 1H‒NMR, Two Dimensional 1H,1H Gradient Enhanced Nuclear Overhauser Effect spectroscopy (NOESY), One-Dimensional Steady-State Intermolecular 13C,1H NOE, and Molecular Dynamics Study”. A. Troganis, I.P. Gerothanassis*, Z. Athanassiou, T. Mavromou-stakos, G.E. Hawkes and C. Sakarellos, Biopolymers, 53, 72-83 (2000). UoI.

 72. “(2+4)-Cycloaddition with Singlet Oxygen. 17O-Investigation of the Reactivity of Furfuryl Alcohol Endoperoxide”. A.M. Braun*, H. Dahn, E. Gassmann, I.P. Gerothanassis, L. Jakob, J. Kateva, C.G. Martinez and E. Oliveros, J. Photochem. Photobiology, 70 (6), 868-874 (1999). Univ. of Lausanne.

 71. “Carbon-13 and Oxygen-17 Chemical Shifts, (16O/18O) Isotope Effects on 13C Chemical Shifts, and Vibrational Frequencies of Carbon Monoxide in Various Solvents and of the Fe‒C‒O Unit in Carbonmonoxy Heme Proteins and Synthetic Model Compounds”. C.G. Kalodimos, I.P. Gerothanassis*, R. Pierattelli and B. Ancian, Inorg. Chem., 38, 4283-4293 (1999). UoI.

 70. “Iron-57 Nuclear Shieldings as a Quantitative Tool for Estimating Porphryrin Ruffling in Hexacoordinated Carbonmonoxy Heme Model Compounds in Solution”. C.G. Kalodimos I.P. Gerothanassis*, E. Rose, G.E. Hawkes and R. Pierattelli, J. Am. Chem. Soc., 121, 2903-2908 (1999). UoI.

 69. “Design and Synthesis of a Potent Cyclic Analogue of the Myelin Basic Protein Epitope MBP72-85: Importance of the Ala81 Carboxyl Group and of a Cyclic Conformation for Induction of Experimental Allergic Encephalomyelitis”. T. Tselios, L. Probert, I. Daliani, E. Matsoukas, A. Troganis, I.P. Gerothanassis, T. Mavromoustakos, G.J. Moore and J.M. Matsoukas*, J. Med. Chem., 42, 1170-1177 (1999). UoI.

 68. “Heteronuclear NMR Applications (O, S, Se and Te)”. I.P. Gerothanassis, in Encyclopedia of Spectroscopy & Spectrometry (J.C. Lindon, G.E. Tranter and J.L. Holmes, eds.), Academic Press, pp. 722-729 (1999). UoI.

 67. “Methodology for Identification of Phenolic Acids in Complex Phenolic Mixtures by High-Resolution Two- Dimensional Nuclear Magnetic Resonance. Application to Methanolic Extracts of Two Oregano Species”. I.P. Gerothanassis*, V. Exarchou,
V. Lagouri, A. Troganis, M. Tsimidou and D. Boskou*, J. Agric. Food Chem., 46, 4185-4192 (1998). UoI.

 66. “Rare M7O2 Double Tetrahedral Core in Molecular Species: Preparation, Structure and Properties of [Zn7O2(O2CMe)10 (1-Meim)2] (1-Meim=1-methylimidazole) ”. N. Lalioti, C.P. Raptopoulou, A. Terzis, A.E. Aliev, S.P. Perlepes*, I.P. Gerothanassis* and E. Manessi-Zoupa*, Chem. Commun., 1513-1514 (1998). UoI.

 65. “Carbon-13 Nuclear Shieldings as a Novel Method in Estimating Porphyrin Ruffling in Hexacoordinated Superstructured Heme Model Compounds in Solution”. C.G. Kalodimos and I.P. Gerothanassis*, J. Am. Chem. Soc., 120, 6407-6408 (1998). UoI.

 64. “13C and 57Fe - NMR Studies of the Fe‒C‒O Unit of Heme Proteins and Synthetic Model Compounds in Solution: Comparison with IR Vibrational Frequencies and X-ray Structural Data”. C.G. Kalodimos, I.P. Gerothanassis* and G.E. Hawkes, Biospectroscopy, 4, S57-S69 (1998). UoI.

 63. “The Effects of Atropisomerism and Porphyrin Deformation on 57Fe Shieldings in Superstructured Hemoprotein Models”. I.P. Gerothanassis*, C.G. Kalodimos, G.E. Hawkes and P. Haycock, J. Magn. Reson., 131, 163-165 (1998). UoI.

 62. “13C Shieldings, 18O Isotope Effects on 13C Shieldings, and 57Fe‒13C spin Couplings of the Fe‒C‒O Unit in Superstructured Hemoprotein Models: Comparison with Hemoproteins, C‒O Vibrational Frequencies, and X-ray Structural Data”. C.G. Kalodimos, I.P. Gerothanassis*, A. Troganis, B. Loock and M. Momenteau, J. Biomol. NMR, 11, 1-13 (1998). UoI.

 61. “Experimental Evidence of Specific Solute-Solvent Interactions of Fullerenes C60 and C70 in Solution: One Dimensional Steady-State Intermolecular 13C, 1H Overhauser Effect Study”. A. Troganis, I.P. Gerothanassis* and D.K. Papademitriou, J. Magn. Reson., 130, 149-152 (1998). UoI.

 60. “Solvent Effects on Oxygen-17 Chemical Shifts in Amides. Quantitative Linear Solvation Shift Relationships”. E. Diez*, J.S. Fabian, I.P. Gerothanassis, A.L. Esteban, J.L.M. Abboud, R.H. Contreras and D.G.de Kowalewski, J. Magn. Reson., 124, 8-19 (1997). UoI.

 59. “The First Experimental Evidence of Differential Hydration of E/Z Isomers of Sterically Hindered Amides: One Dimensional Steady-State Selective Intermolecular 13C, 1H Overhauser Effect Study of Tert-butylformamide”. I.P. Gerothanassis*, A. Troganis and C. Vakka, Tetrahedron Lett., 37, 6569-6572 (1996). UoI.

 58. “Complexes of Zn2+, Cd2+ and Hg2+ with 2-(α-Hydroxybenzyl)thiamine Monophosphate Chloride”. K. Dodi, I.P. Gerothanassis, N. Hadjiliadis*, A. Schreiber, R. Bau, I.S. Butler and P.J. Barrie, Inorg. Chem., 35, 6513-6519 (1996). UoI.

 57. “17O NMR Studies of Electronic and Steric Interactions of Substituted Quinoxaline-2(1H), 3(4H)-diones”. I.P. Gerothanassis* and G. Varvounis, J. Heterocyclic Chem., 33, 643-646 (1996). UoI.

 56. “17O and 14N NMR Studies of Quinoxaline-2(1H), 3(4H)-diones and N,N’-Substituted Oxamides: The First Experimental Evidence of Torsion Angle Deformation Resulting from an Unprecedented Through Six-bond Substituent Effect  on the Diamide Group of Quinoxaline-2(1H), 3(4H)-diones”. I.P. Gerothanassis*, J. Cobb, A. Kimbaris, J.A.S. Smith and G. Varvounis, Tetrahedron Lett, 37, 3191-3194 (1996). UoI.

 55. “13C CP/MAS NMR Studies of Hemoprotein Models with and Without an Axial Hindered Base: 13C Shielding Tensors and Comparison With Hemoproteins and X-Ray Structural Data”. I.P. Gerothanassis*, M. Momenteau*, P.J. Barrie, C.G. Kalodimos and G.E. Hawkes, Inorg. Chem., 35, 2674-2679 (1996). UoI.

 54. “17O NMR Studies of the Solvation State of Cis/Trans Isomers of Amides and Model Protected Peptides”. I.P. Gerothanassis*, C. Vakka and A. Troganis, J. Magn. Reson. B, 111, 220-229 (1996). UoI.

 53. “Ab Initio Molecular Orbital Calculations of Solvent Clusters of Trans-N-methyl-acetamide: Structure, Ring Cluster Formation and Out-of-Plane Deformation”. I.N. Demetropoulos*, I.P. Gerothanassis*, C. Vakka and C. Kakavas, J. Chem. Soc., Faraday Trans., 92, 921-931 (1996). UoI.

*52. “NMR Shielding and the Periodic Table”. I.P. Gerothanassis* and C.G. Kalodimos, J. Chem. Educ., 73, 801-804 (1996). UoI.

*51. “Nuclear Electric Quadrupole Relaxation”. I.P. Gerothanassis* and C.G. Tsanaktsidis, Concepts Magn. Reson. 8, 63-74 (1996). UoI.

 50. “31P Solid-State NMR Measurements Used to Detect Interactions Between NADPH and Water and to Determine the Ionisation State of NADPH in a Protein-Ligand Complex Subjected to Low-level Hydration”. I.P. Gerothanassis*, P.J. Barrie, B. Birdsall and J. Feeney*, Eur. J. Biochem., 235, 262-266 (1996). UoI.

 49. “Oxygen-17”. I.P. Gerothanassis, in Encyclopedia of Nuclear Magnetic Resonance (D.M. Grant and R.K. Harris, eds), Wiley, Baffins Lane, Chichester, pp. 3430-3440 (1995). UoI.

 48. “Measuring the 13C NMR Shielding Tensor of 13CO Bonded to Haemoglobin”. P.J. Barrie*, I.P. Gerothanassis, M. Momenteau and G.E. Hawkes, J. Magn. Reson. B, 108, 185-188 (1995). UoI.

 47. “17O and 1H‒15N Heteronuclear Multiple Quantum Coherence (1H‒15N HMQC) NMR of Linear Amides: Evidence of an Out-of-Plane (Torsion Angle) Deformation of the Amide Bond and Pyramidicity at the Amide Nitrogen”. I.P. Gerothanassis*, A. Troganis and C. Vakka, Tetrahedron, 51, 9493-9500 (1995). UoI.

 46. “Hydration of Cis and Trans N - Methylformamide as Revealed by the Use of 17O NMR, Molecular Mechanics and Ab Initio Calculations”. I.P. Gerothanassis*, I.N. Demetropoulos* and C. Vakka, Biopolymers, 36, 415-428 (1995). UoI.

 45. “NMR Studies of Ligand-Protein Interactions Involving Quadrupolar Nuclei”. I.P. Gerothanassis, in NMR of Biological Macromolecules (C. Stasinopoulou, ed.), Springer-Verlag, Berlin, pp. 155-170 (1994). UoI.

 44. “Nuclear Shielding and Biomolecular Structure”. I.P. Gerothanassis, in NMR of Biological Macromolecules (C. Stasinopoulou, ed.), Springer-Verlag, Berlin, pp. 87-114 (1994). UoI.

 43. “Observation of Large Solvent Effects on the 31P Shielding Tensor of a Cyclic Nucleotide”. I.P. Gerothanassis*, P.J. Barrie* and C. Tsanaktsidis, J. Chem. Soc., Chem. Commun., 2639-2640 (1994). UoI.

 42. “31P - NMR Studies of NADPH, NADP+ and the Complex of NADPH and Methotrexate with Lactobacillus casei Dihydrofolate Reductase in the Solid State”. I.P. Gerothanassis, P.J. Barrie, B. Birdsall and J. Feeney*, Eur. J. Biochem., 226, 211-218 (1994). Medical Research Institute, London.

 41. “Solid State 13C NMR Evidence for a Large Deviation from Linearity of the Fe‒C‒O Unit in the CO Complex with Myoglobin”. I.P. Gerothanassis*, P.J. Barrie*, M. Momenteau and G.E. Hawkes, J. Am. Chem. Soc., 116, 11944-11949 (1994). UoI.

 40. “17O NMR Chemical Shifts as a Tool to Study Specific Hydration Sites of Amides and Peptides - Correlation with the IR Amide I Stretching Vibration”. I.P. Gerothanassis* and C. Vakka, J. Org. Chem., 59, 2341-2348 (1994). UoI.

 39. “17O NMR Studies of Hemoproteins and Synthetic Model Compounds in the Solution and Solid States”. I.P. Gerothanassis, Progr. NMR Spectrosc., 26, 239-292 (1994). UoI.

 38. “Multinuclear and Multidimensional NMR Methodology for Studying Individual Water Molecules Bound to Peptides and Proteins in Solution: Principles and Applications”. I.P. Gerothanassis, Progr. NMR Spectrosc., 26,171-237 (1994). UoI.

 37. “Is the Iron-Carbon-Oxygen Moiety Linear or Bent in Heme Model Compounds? Evidence for Non-Axially Symmetric Shielding Tensors from Carbon-13 CP MAS NMR Spectroscopy”. I.P. Gerothanassis*, M. Momenteau, G.E. Hawkes and P.J. Barrie, J. Am. Chem. Soc., 115, 9796-9797 (1993). UoI.

 36. “Applications of Nuclear Shielding”. I.P. Gerothanassis, C. Efthimiou and C. Vakka, Nuclear Magnetic Resonance, 22, 90-137 (1993). UoI.

 35. “Solvation State of the Tyr Side Chain in Peptides. An FT‒IR and 17O‒NMR Approach”. I.P. Gerothanassis*, Ν. Birlirakis, C. Sakarellos* and M. Marraud, J. Am. Chem. Soc., 114, 9043-9047 (1992). UoI.

 34. “Hydration of Gly2 and Gly3 Peptide Oxygens of [Leu5]-enkephalin in Aqueous Solution as Revealed by the Combined Use of 17O‒NMR and Fourier- Transform Infrared Spectroscopy”. I.P. Gerothanassis*, N. Birlirakis, T. Karayannis, M. Sakarellos-Daitsiotis, C. Sakarellos*, B. Vitoux and M. Marraud, Eur. J. Biochem., 210, 693-698 (1992). UoI.

 33. “NMR Detection of Bound Water Molecules in the Active Site of Lactobacillus casei Dihydrofolate Reductase in Aqueous Solution”. I.P. Gerothanassis, B. Birdsall, C.J. Bauer, T.A. Frenkiel and J. Feeney*, J. Mol. Biol., 226, 549-554 (1992). Medical Research Institute, London.

 32. “Structural Differences of the Iron-Dioxygen Moiety of Haemoprotein Models with and without Axial Hindered Base as Revealed by 17O NMR and FTIR Spectroscopy in Solution”. I.P. Gerothanassis*, B. Loock and M. Momenteau*, J. Chem. Soc., Chem. Commun., 598-600 (1992). UoI.

 31. “17O‒NMR and FT-IR Study of the Ionization State of Peptides in Aprotic Solvents. Application to Leu-enkephalin”. I.P. Gerothanassis*, N. Birlirakis, T. Karayannis, V. Tsikaris, M. Sakarellos-Daitsiotis, C. Sakarellos, B. Vitoux and M. Marraud, FEBS Letters, 298, 188-190 (1992). UoI.

 30. “31P NMR Assignment and Conformational Study of NADPH Bound to Lactobacillus casei Dihydrofolate Reductase Based on two-Dimensional 1H‒31P - Heteronuclear and 1H Detected 1H‒31P - Shift Correlation Experiments”. I.P. Gerothanassis, B. Birdsall, C.J. Bauer and J. Feeney*, Eur. J. Biochem., 204, 173-177 (1992). Medical Research Institute, London.

 29. “Applications of Nuclear Shielding”. I.P. Gerothanassis and C. Efthimiou, Nuclear Magnetic Resonance, 21, 70-105 (1992). UoI.

 28. “Hydrogen Bonding Effects on 31P NMR Shielding in the Pyrophosphate Group of NADPH Bound to L.Casei Dihydrofolate Reductase”. I.P. Gerothanassis*, B. Birdsall and J. Feeney, FEBS Letters, 291, 21-23 (1991). Medical Research Institute, London.

 27. “Applications of Nuclear Shielding”. I.P. Gerothanassis, Nuclear Magnetic Resonance, 20, 81-111 (1991). UoI.

 26. “17O NMR Relaxation Times of the Protein Amino Acids in Aqueous Solution. Estimation of the Relative Hydration Numbers in the Cationic, Anionic and Zwitterionic Forms”. J. Lauterwein*, I.P. Gerothanassis, R.N. Hunston and M. Schumacher, J. Phys. Chem., 95, 3804-3811 (1991). Univ. of Lausanne.

 25. “Does a 2¬5 β -turn Structure Exist in Enkephalins? Study of a Fully Protected Leu-enkephalin in Organic Solution by 17O NMR”. E. Moret, I.P. Gerothanassis, R.N. Hunston and J. Lauterwein*, FEBS Letters 262, 173-175 (1990). Univ. of Lausanne

 24. “Applications of Nuclear Shielding”. I.P. Gerothanassis, Nuclear Magnetic Resonance, 19, 34-79 (1990). UoI.

 23. “17O and 14N - NMR Studies of Leu-enkephalin and Enkephalin - Related Fragments in Aqueous Solution”. T. Karayannis, I.P. Gerothanassis*, M. Sakarellos-Daitsiotis, C. Sakarellos and M. Marraud, Biopolymers, 29, 423-439 (1990). UoI.

 22. “17O‒NMR Spectroscopy as a Novel Tool of Investigating‚ β-turn in Model Peptides”. N. Birlirakis, I.P. Gerothanassis, C. Sakarellos* and M. Marraud, J. Chem. Soc., Chem. Commun., 1122-1123 (1989). UoI.

 21. “Hydrogen-Bond Stabilization of Dioxygen, Conformation Excitation, and Autoxidation Mechanism in Hemoprotein Models as Revealed by 17O NMR Spectroscopy”. I.P. Gerothanassis*, M. Momenteau* and B. Loock, J. Am. Chem. Soc., 111, 7006-7012 (1989). UoI.

 20. “17O‒NMR Studies of the Conformational and Dynamic Properties of Enkephalins in Aqueous and Organic Solutions Using Selectively Labeled Analogues”. C. Sakarellos, I.P. Gerothanassis, N. Birlirakis, T. Karayannis, M. Sakarellos-Daitsiotis and M. Marraud, Biopolymers, 28, 15-26 (1989). UoI.

 19. “Multiple-Quantum 1H‒15N Chemical Shift Correlation Spectroscopy of the Peptide Hormone Leu-enkephalin in Solution”. I.P. Gerothanassis*, M. Bourdonneau,
T. Karayannis, M. Sakarellos-Daitsiotis and C. Sakarellos, J. Magn. Reson., 80, 309-313 (1988). UoI.

 18. “Effectiveness of Pulse Sequences for Suppression of Acoustic Ringing in FT NMR”. I.P. Gerothanassis, J. Magn. Reson., 75, 361-363 (1987). UoI.

 17. “17O NMR Spectroscopy as a Tool for Studying Synthetic Oxygen Carriers Related to Biological Systems: Application to a Synthetic Single-Face Hindered Iron Porphyrin-Dioxygen Complex in Solution”. I.P. Gerothanassis* and M. Momenteau, J. Am. Chem. Soc., 109, 6944-6947 (1987). UoI.

 16. “Nitrogen-14 Nuclear Magnetic Resonance of the Amino Terminal Group of Leu-enkephalin in Aqueous Solution”. I.P. Gerothanassis*, T. Karayannis, M. Sakarellos-Daitsiotis, C. Sakarellos and M. Marraud, J. Magn. Reson., 75, 513-516 (1987). UoI.

 15. “Methods of Avoiding the Effects of Acoustic Ringing in Pulsed FT NMR Spectroscopy”. I.P. Gerothanassis, Progr. NMR Spectrosc., 19, 267-329 (1987). UoI.

 14. “17O NMR Spectroscopy: Referencing in Diamagnetic and Paramagnetic Solutions”.
I.P. Gerothanassis and J. Lauterwein*, Magn. Reson. Chem., 24, 1034-1038 (1986). Univ. of Lausanne.

 13. “Simple Reference Baseline Subtraction-90° Pulse Sequence for Acoustic Ringing Elimination in Pulsed Fourier Transform NMR Spectroscopy”. I.P. Gerothanassis, Magn. Reson. Chem., 24, 428-433 (1986). UoI.

 12. “An Evaluation of Various Pulse Sequences for the Suppression of Acoustic Ringing in Oxygen-17 NMR”. I.P. Gerothanassis and J. Lauterwein*, J. Magn. Reson., 66, 32-42 (1986). Univ. of Lausanne.

 11. “17O NMR Chemical Shifts of the Twenty Protein Amino Acids in Aqueous Solution”.
I.P. Gerothanassis, R.N. Hunston and J. Lauterwein*, Magn. Reson. Chem., 23, 659-665 (1985). Univ. of Lausanne.

 10. “A Study of L-Proline, Sarcosine and the Cis/Trans Isomers of N-Acetyl-L-proline and N-Acetylsarcosine in Aqueous and Organic Solution by 17O NMR”. R.N. Hunston, I.P. Gerothanassis and J. Lauterwein*, J. Am. Chem. Soc., 107, 2654-2661 (1985). Univ. of Lausanne.

  9.  “A study of the Cis/Trans Isomerism of N-Acetyl-L-Proline in Aqueous Solution by 17O NMR Spectroscopy”. J. Lauterwein*, I.P. Gerothanassis and R. Hunston, J. Chem. Soc., Chem. Commun., 367-369 (1984). Univ. of Lausanne.

  8.  “Acquisition Times, Relaxation Rates and Solvent and Temperature Effects as Sensitivity Parameters for Quadrupolar Nuclei”. I.P. Gerothanassis, Org. Magn. Reson., 21, 719-722 (1983). Univ. of East Anglia.

  7.  “Calculation of Transverse Relaxation Times from Lineshapes Modified by Gaussian-Exponential Filtering”. G. Braoudakis, I.P. Gerothanassis and J. Lauterwein*, J. Magn. Reson., 52, 288-292 (1983). Univ. of Lausanne.

  6.  “Application of a Steady-State Pulse Sequence for Solvent Elimination in 17O‒NMR”. J. Lauterwein* and I.P. Gerothanassis, J. Magn. Reson., 51, 153-156 (1983). Univ. of Lausanne.

  5.  “17O-NMR of Enriched Acetic Acid, Glycine, Glutamic Acid and Aspartic Acid in Aqueous Solution. II. Relaxation Studies”. I.P. Gerothanassis, R. Hunston and J. Lauterwein*, Helv. Chim. Acta, 65, 1774-1784 (1982). Univ. of Lausanne.

  4.  “17O-NMR of Enriched Acetic Acid, Glycine, Glutamic Acid and Aspartic Acid in Aqueous Solution. I. Chemical Shift Studies”. I.P. Gerothanassis, R. Hunston and J. Lauterwein*, Helv. Chim. Acta, 65, 1764-1773 (1982). Univ. of Lausanne.

  3.  “Natural - Abundance 17O-NMR of Monosaccharides”. I.P. Gerothanassis, J. Lauter-wein* and N. Sheppard, J. Magn. Reson., 48, 431-446 (1982). Univ. of Lausanne

  2.  “Natural Abundance 17O-NMR Spectra of Some Inorganic and Biologically Important Phosphates”. I.P. Gerothanassis and N. Sheppard, J. Magn. Reson., 46, 423-439 (1982). Univ. of East Anglia.

  1. “17O Nuclear Magnetic Resonance Studies of Some Enriched Amino Acids”. R. Hunston, I.P. Gerothanassis and J. Lauterwein*, Org. Magn. Reson., 18, 120-121 (1982). Univ. of Lausanne.

year

2005

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2007

2008

2009

2010

2011

2012

2013

2014

2015

2016

2017

2018

publications

4

3

2

1

2

4

4

8

6

9

5

5

5

1

 

citations

109

105

96

130

116

217

129

176

198

241

228

206

275

10

 

*publications in databases recognised for elections into scientific-teaching and teaching grades

Research Publications

Publications in Proceedings of International Conferences

59. “Enriching the biologically relevant space sampled by natural products through biotransformations: speeding up the natural-product based drug discovery process”. A.G. Tzakos, A. Chatzikonstantinou, I.P. Gerothanassis, M. Chatziathanasiadou, C. Stamatis and N. Sayyad. Planta Med. 81, SL3B_05 (2015). UoI.

58. “On the Hydration State of Amino Acids and Their Derivatives at Different Ionization States: A Comparative Multinuclear NMR and Crystallographic Investigation”. C.Pappas, A.G. Tzakos and I.P. Gerothanassis, J. Pept. Sci. 18, Suppl. 1, S165-S165 (2012).

57.  “Recognition Pliability is Coupled to Structural Heterogeneity: a Calmodulin-Intrinsically Disordered Binding Region Complex”. M. Nagulapalli, G. Parigi, J. Yuan et al. J. Pept. Sci. 18, Suppl. 524-524 (2012).

56.  “Evolution of a Molecular Switch by a Single Mutation Surmounts the Chloride Ion Dependent mechanism of ACE” N. Nawarish, J. Gsponer, A. Husccin, I.P. Gerothanassis, M.M. Babu and A. Tzakos, FEBS Journal 275, Suppl. 1, 178-178 (2008).

55.  “An NMR Study of the Interaction between Bradykinin and Angiotensin-I and Synthetic Peptide-based Angiotensin-I Converting Enzyme Catalytic Size Maquettes (CSM)”. A.S. Galaris, Z. Spyranti, N.Tsam, G.A. Spyroulias, E. Manessi-Zoupa, G. Pairas, I.P. Gerothanassis and P.Cordopatis, J. Pept. Sci. 12, S196-S196 (2006).

54.  “Selection of Captopril Isomerization States by Human Angiotensin I Converting Enzyme (hACE)”. A.G. Tzakos, N. Naqvi, K. Comporozos, R. Pierattelli, V. Theodorou, I.P. Gerothanassis and A. Husain, J. FASEB, 20 (4): 50-52, 6 (2006).

53.  “NMR Models of the Angiotensin-I Converting Enzyme Zn(II) Catalytic Sites: the Basis for a Structural Study on the Enzyme-Substrate Interaction”. G.A. Spyroulias, A.S. Galaris, G. Pairas, E. Manessi-Zoupa, I.P. Gerothanassis and  P. Cordopatis, FEBS J. 272, S1, 566-566 (2005).

52.  “Structural Studies and Sequence Homology Investigations of the Guinea Pig Myelin Basic Protein (MBP) Epitope 74-85 Analogues”. A. Tzakos, P. Fuchs, N.A.J. van Nuland, A. Troganis, T. Tselios, S. Deraos, G. Deraos, I.P. Gerothanassis, A.M.J.J. Bonvin and J. Matsoukas, Biopolymers, 71 (3): P514 (2003).

51.  “1H and 13C NMR Assignment and Conformational Studies of Myelin Basic Protein Epitope 74-85 Implicated in Multiple Sclerosis”. Α. Tzakos, A. N. Troganis, T. Tselios, A. Bonvin, N. van Nuland, S. Deraos, J. Matsoukas and I.P. Gerothanassis, in Drug Discovery and Design: Medical Aspects, (J. Matsoukas and T. Mavromoustakos, Eds.), Ios Press 180-187 (2002).

50.  “Direct Observation of Discrete Conformational Transitions in Progressively Hydrated Nucleosides and Nucleotides by the use of C-13 CP/MAS NMR Spectroscopy”. K. Barbarossou, A.E. Aliev, I.P. Gerothanassis and T. Vaimakis, J. Inorg. Biochem. 86, 1, 137-137 (2001).

49.  “Conformational Studies of Angiotensin II – Metal Complexes by NMR Spectroscopy”. A. Tzakos, A. Troganis, R. Pieratteli, I.P. Gerothanassis, A. Bonvin, N. Van Nuland and P. Cordopatis, in Journal of Inorganic Biochemistry, 86, 462 (2001).

48.  “Conformational Analysis of Angiotensin II and Analogues by the Use of Two Dimensional Gradient NMR Spectroscopy”. A. Tzakos, A. Troganis, I.P. Gerothanassis, M. Assimomytis, V. Magafa, E. Manesi-Zoupa, G. Pairas and P. Cordopatis, in 2nd Hellenic Forum on Bioactive Peptides (P.A. Cordopatis, Ed.), pp. 433-438 (2001).

47.  “Enthalpy and Entropy Changes of Cis and Trans Isomers in Distorted Amides Compared to Planar Amides and Model Peptides: A Variable Temperature 1H‒NMR Study”. A.N. Troganis, S. Bravou and I.P. Gerothanassis, in 2nd Hellenic Forum on Bioactive Peptides (P.A. Cordopatis, Ed.), pp. 419-424 (2001).

46.  “The Triad: NMR, Biomolecular Structure, Thermodynamics”. I.P. Gerothanassis, in 2nd Hellenic Forum on Bioactive Peptides (P.A. Cordopatis, Ed.), pp. 77-84 (2001).

45.  “NMR Methodology for the Analysis of Phenolic Acids in Complex Natural Mixtures”. V. Exarchou, I.P. Gerothanassis, A. Troganis, M. Tsimidou and D. Boskou in Instrumental Methods of Analysis: Modern Trends and Applications (M. Schsenkuhn-Petropulu and K.M. Ochsenkuhm, Eds.), vol. 1, pp. 110-114 (1999).

44.  “Nuclear Magnetic Resonance Studies of Peptide Analogues of the Myelin Basic Protein Epitope MBP72-85”. A. Troganis, I.P. Gerothanassis, T. Mavromoustakas, I. Deliani, T. Tselios, E. Matsoukas and J.M. Matsoukas, in Spectroscopy of Biological Molecules: New Directions (J. Greve, G.J. Puppels and C. Otto, Eds.), pp. 589-590, Kluwer Academic Publishers, Dordrecht, Netherlands (1999).

43.  “NMR Methodology for the Analysis of Phenolic Acids in Complex Phenolic Mixtures”. I.P. Gerothanassis, V. Exarchou, A. Troganis, M. Tsimidou and D. Boskou, in Spectroscopy of Biological Molecules: New Directions (J. Greve, G.J. Puppels and C. Otto, Eds.), pp. 585-586, Kluwer Academic Publishers, Dordrecht, Netherlands (1999)

42.  “NMR Spectroscopic Methodologies for Investigating Porphyrin Ruffling in Hemoproteins and Model Compounds”. C.G. Kalodimos and I.P. Gerothanassis, in Spectroscopy of Biological Molecules: New Directions (J. Greve, G.J. Puppels and C. Otto, Eds.), pp.167-68, Kluwer Academic Publishers, Dordrecht, Netherlands (1999).

41.  “Thermodynamic Origin of Cis/Trans Isomers of N-substituted Amides and a Proline-Containing β-turn Model dipeptide in Aqueous Solution: A Variable Temperature Gradient Enhanced 1H‒NMR Study”. Z. Athanassiou, A. Troganis and I.P. Gerothanassis, in Spectroscopy of Biological Molecules: New Directions (J. Greve, G.J. Puppels and C. Otto, Eds.), pp. 55-56, Kluwer Academic Publishers, Dordrecht, Netherlands (1999).

40.  “ΝΜR Studies of the Active Site of Hemoproteins and Synthetic Model Compounds”. I.P. Gerothanassis and C.G. Kalodimos, in Bioactive Peptides in Drug Discovery and Design: Medical Aspects (J. Matsoukas and T. Mavromoustakas, Eds.), pp. 195-202, IOS Press, Amsterdam (1999).

39.  “17O NMR Studies of Electronic and Steric Interactions of Quinoxaline -2(1H), 3(4H)-dione Derivatives”. I.P. Gerothanassis and G. Varvounis, in Spectroscopy of Biological Molecules: Modern Trends (P. Carmona, R. Navarro and A. Hernanz, Eds.), pp. 623-624, Kluwer Academic Publishers, Netherlands (1997).

38.  “On the Axial Ligand Orientation of Heme Proteins and Model Compounds”. C.G. Kalodimos, I.P. Gerothanassis, A. Troganis and M. Momenteau, in Spectroscopy of Biological Molecules: Modern Trends (P. Carmona, R. Navarro and A. Hernanz, Eds.), pp. 77-78, Kluwer Academic Publishers, Netherlands (1997).

37.  “18O Isotope Effects on 13C Shieldings and 57Fe–13C Spin Couplings of the Fe–C–O Unit in Superstructured Hemoprotein Models”. C.G. Kalodimos, I.P. Gerothanassis, A. Troganis and M. Momenteau, in Spectroscopy of Biological Molecules: Modern Trends (P. Carmona, R. Navarro and A. Hernanz, Eds.), pp. 75-76, Kluwer Academic Publishers, Netherlands (1997).

36.  “Multinuclear NMR Studies of Hemoproteins and Synthetic Model Compounds in Solution and in the Solid State”. I.P. Gerothanassis, C.G. Kalodimos and M. Momenteau, in Spectroscopy of Biological Molecules: Modern Trends (P. Carmona, R. Navarro and A. Hernanz, Eds.), pp.63-66, Kluwer Academic Publishers, Netherlands (1997).

35.  “One Dimensional 13C–1H Nuclear Overhauser Effect Experiments in Elucidating Solute-Solvent Interactions of Cis/Trans Isomers of β-turn Model Peptides”. I.P. Gerothanassis, A. Troganis and C. Sakarellos, in Spectroscopy of Biological Molecules: Modern Trends (P. Carmona, R. Navarro and A. Hernanz, Eds.), pp.47-48, Kluwer Academic Publishers, Netherlands (1997).

34.  “One- and Two- Dimensional 13C–1H Nuclear Overhauser Effect Experiments in Elucidating Solute-Solvent Interactions in Amides and Peptides: Methodology and Applications”. A. Troganis and I.P. Gerothanassis, in Spectroscopy of Biological Molecules: Modern Trends (P. Carmona, R. Navarro and A. Hernanz, Eds.), pp.45-46, Kluwer Academic Publishers, Netherlands (1997).

33.  “Multinuclear NMR Studies of Hemoproteins and Synthetic Model Compounds in Solution and in the Solid State”. I.P. Gerothanassis, C.G. Kalodimos and M. Momenteau, Hellenic Forum on Bioactive Peptides, pp.151-160, Crete University Press (1997).

32.  “Ab Initio Molecular Orbital Calculations of Solvent Clusters of Trans-N-methylacetamide”. I.N. Demetropoulos, I.P. Gerothanassis, C. Vakka and C. Kakavas, in Molecular Properties and Chemistry of Biological Systems (N. Hatziliadis and M. Fasano, Eds.), pp. 37-42, Edizioni Dell' Orso (1996).

31.  “Hydration of Cis and Trans N-Methyl Formamide as Revealed by the Use of 17O NMR and Molecular Mechanics Calculations”. I.P. Gerothanassis, I.N. Demetropoulos and C. Vakka, in Molecular Properties and Chemistry of Biological Systems (N. Hatziliadis and M. Fasano, Eds.), pp. 173-178, Edizioni Dell' Orso (1996).

30.  “The Role of Water in the Deformation of the Peptide Unit and the Formation of a Chiral Center at the Amide Nitrogen. Ab Initio Studies of Amide-Water Clusters”. I.P. Gerothanassis, I.N. Demetropoulos and C. Vakka, in Molecular Properties and Chemistry of Biological Systems (N. Hatziliadis and M. Fasano, Eds.), pp. 167-172, Edizioni Dell' Orso (1996).

29.  “A Solid State 31P NMR Study of the Binding of Zn(II) and Cd(II) to 2-(-Hydroxybenzyl) Thiamine Monophosphate”. I.P. Gerothanassis, K. Dodi, P.J. Barrie and N. Hadjiliadis, in Molecular Properties and Chemistry of Biological Systems (N. Hatziliadis and M. Fasano, Eds.), pp. 161-166, Edizioni Dell' Orso (1996).

28.  “17O NMR of the Solvation State of Cis/Trans Isomers of Amides”. I.P. Gerothanassis, C. Vakka and A. Troganis, in Molecular Properties and Chemistry of Biological Systems (N. Hatziliadis and M. Fasano, Eds.), pp. 155-160, Edizioni Dell' Orso (1996).

27.  “Observation of Large Hydrogen Bonding Effects on the 31P Shielding Tensor of a Cyclic Nucleotide and the NADPH”. I.P. Gerothanassis and C. Tsanaktsidis, in Molecular Properties and Chemistry of Biological Systems (N. Hatziliadis and M. Fasano, Eds.), pp. 149-153, Edizioni Dell' Orso (1996).

26.  “Multinuclear and Multidimensional NMR of Individual Peptide and Protein Bound Water Molecules in Solution and Solid State: Methodology”. I.P. Gerothanassis, in Molecular Properties and Chemistry of Biological Systems (N. Hatziliadis and M. Fasano, Eds.), pp. 143-148, Edizioni Dell' Orso (1996).

25.  “13C NMR Studies of Hemoproteins and Model Compounds in the Solid: Methodology and Applications”. I.P. Gerothanassis, P.J. Barrie, M. Momenteau and G.E. Hawkes, in Spectroscopy of Biological Molecules (J.C. Merlin et al. eds), pp. 241-242, Kluwer Academic Publishers, Dordreht (1995).

24.  “31P NMR Studies of the Complex of NADPH and Methotrexate with Lactobacillus Casei Dihydrofolate Reductase in the Solid State - Comparisons with Studies in Solution”. I.P. Gerothanassis, P.J. Barrie, B. Birdsall and J. Feeney, in Spectroscopy of Biological Molecules (J.C. Merlin et al. eds.), pp. 137-138, Kluwer Academic Publishers, Dordreht (1995).

24.  “31P NMR Studies of the Complex of NADPH and Methotrexate with Lactobacillus Casei Dihydrofolate Reductase in the Solid State - Comparisons with Studies in Solution”. I.P. Gerothanassis, P.J. Barrie, B. Birdsall and J. Feeney, in Spectroscopy of Biological Molecules (J.C. Merlin et al. eds.), pp. 137-138, Kluwer Academic Publishers, Dordreht (1995).

23.  “Hydration State of Cis-Trans Peptide Oxygens of Protected Peptides as Revealed by the Use of 17Ο NMR”. I.P. Gerothanassis, in Spectroscopy of Biological Molecules (J.C. Merlin et al. eds), pp.55-56, Kluwer Academic Publishers, Dordreht (1995).

22.  “Multinuclear and Multidimensional NMR of Specific Molecules of Water Bound to Amides, Peptides and Proteins in Solution and Solid States”. I.P. Gerothanassis, in Spectroscopy of Biological Molecules (J.C. Merlin et al. eds), pp.53-54, Kluwer Academic Publishers, Dordreht (1995).

21.  “Solvation of Amides: Correlation of 17Ο NMR Chemical Shifts with ν(CO) Stretching Vibration”. I.P. Gerothanassis and C. Vakka, in Spectroscopy of Biological Molecules (J.C. Merlin et al. eds.), pp. 51-52, Kluwer Academic Publishers, Dordreht (1995).

20.  “The Role of Water in the Deformation of the Amide Bond: Ab Initio Quantum Mechanics Studies”. I.N. Demetropoulos, I.P. Gerothanassis and C. Vakka, in Spectroscopy of Biological Molecules (J.C. Merlin et al. eds.), pp. 45-46, Kluwer Academic Publishers, Dordreht (1995).

19.  “The First Solvation Sphere of N-methylformamide (NMF) in Water: MM2 (87) Force Field and Ab Initio Studies”. I.N. Demetropoulos, I.P. Gerothanassis and D.G. Papageorgiou, in Spectroscopy of Biological Molecules (J.C. Merlin et al. eds), pp. 43-44, Kluwer Academic Publishers, Dordreht (1995).

18.  “Ab Initio Quantum Mechanics Studies of Amide-Water Clusters”. I.N. Demetropoulos, I.P. Gerothanassis and C. Vakka, in Spectroscopy of Biological Molecules (J.C. Merlin et al. eds.), pp.41-42, Kluwer Academic Publishers, Dordreht (1995).

17.  “Variable Field 14Ν NMR Relaxation Time Studies of Dodecyl Phosphorylcholine Aqueous Micellar Solutions: Conformational and Dynamic Properties”. I.P. Gerothanassis, E. Papamichael and C. Tsanaktzidis, in Fifth International Conference on the Spectroscopy of Biological Molecules (T. Theophanides,  J. Anastassopoulou and N. Fotopoulos, Eds.), pp. 269-270, Kluwer Academic Publishers, Dordrecht (1993).

16.  “On the Nature of C–H---O Interactions of Amides in Solution: An 17O NMR and FTIR Approach”. I.P. Gerothanassis, C. Efthimiou, M. Momenteau and C. Tsanaktzidis, in Fifth International Conference on the Spectroscopy of Biological Molecules (T. Theophanides, J. Anastassopoulou and N. Fotopoulos, Eds.), pp. 251-252, Kluwer Academic Publishers, Dordrecht (1993).

15.  “Molecular Conformations, Hydrogen Bonding and Hydration State of N-acetyl-L-proline-N’-methylamide: An 17O and 13C NMR Approach”. I.P. Gerothanassis and J. Lauterwein, in Fifth International Conference on the Spectroscopy of Biological Molecules (T. Theophanides, J. Anastassopoulou and N. Fotopoulos, Eds.), pp. 249-250, Kluwer Academic Publishers, Dordrecht (1993).

14.  “17O NMR Chemical Shift and Amide I Stretching Vibration as a Tool to Study Specific Hydration Sites of Amides and Peptides”. C. Vakka, I.P. Gerothanassis and C. Efthimiou, in Fifth International Conference on the Spectroscopy of Biological Molecules (T. Theophanides, J. Anastassopoulou and N. Fotopoulos, Eds.), pp. 247-248, Kluwer Academic Publishers, Dordrecht (1993).

13.  “17O NMR and FTIR Studies of Haemoproteins and Synthetic Model Compounds in Solution and in the Solid State”. I.P. Gerothanassis and M. Momenteau, in Fifth International Conference on the Spectroscopy of Biological Molecules (T. Theophanides, J. Anastassopoulou and N. Fotopoulos, Eds.), pp. 213-216, Kluwer Academic Publishers (1993).

12.  “Fourier Transform IR and Multinuclear and Multidimensional NMR Spectroscopic Studies of Specific Peptide and Protein-Bound Water Molecules”. I.P. Gerothanassis, in Fifth International Conference on the Spectroscopy of Biological Molecules (T. Theophanides, J. Anastassopoulou and N. Fotopoulos, Eds.), pp. 209-212, Kluwer Academic Publishers, Dordreht (1993).

11.  “Does Hydration Contribute to the Minor Occurrence of cis-Peptide Units in Amides and Peptides? Evidence from 17O NMR Spectroscopy and Theoretical Calculations”. C. Vakka, I.P. Gerothanassis and I. Demetropoulos, in Fifth International Conference on the Spectroscopy of Biological Molecules (T. Theophanides, J. Anastassopoulou and N. Fotopoulos, Eds.), pp. 129-130, Kluwer Academic Publishers, Dordrecht (1993).

10.  “Application of Multinuclear and Multidimensional NMR Spectroscopy to the Direct Study of Peptide- and Protein-Bound Water Molecules”. I.P. Gerothanassis, Peptides 1992, Proc. 22nd Eur. Pept. Symp. (C.H. Schneider and A.N. Eberle, Eds.), pp.951-952, ESCOM Science Publishers B.V., Leiden (1993).

  9.  “17O NMR Studies of Oxygenated Heamoproteins and Synthetic Model Compounds”. I.P. Gerothanassis and M. Momenteau, in Metal Ions in Biology and Medicine
(J. Anastassopoulou, P. Collery, J.C. Etienne and T. Theophanides, Eds.), Vol.2, pp.14-19, John Libbey (1992).

  8.  “Solvation State of Leu- enkephalin in Phospholipid Micellar Environment as Revealed by FTIR Studies”. N. Birlirakis, I.P. Gerothanassis, M. Sakarellos-Daitsiotis, C. Sakarellos, B. Vitoux and M. Marraud, Peptides: Chemistry, Structure and Biology (J.E. Rivier and G.R. Marshall, Eds.), The Netherlands, ESCOM, Leiden, pp. 351-352 (1991).

  7.  “FT-IR and Oxygen-17 NMR Studies of Peptide Hydration. The Case of N-acetylated Amino Acid Derivatives”. F. Tete, B. Vitoux, M. Sakarellos-Daitsiotis, I.P. Gerothanassis, N. Birlirakis, T. Karayannis and C. Sakarellos, Peptides 1988, Proc. 20th Eur. Pept. Symp. (E. Bayer and G. Jung, Eds.), Walter de Gruyter, Berlin, pp.531-533 (1989).

  6.  “17Ο NMR and FT-IR Study of Hydration of Leu-enkephalin”. C. Sakarellos, I.P. Gerothanassis, N. Birlirakis, T. Karayannis, M. Sakarellos-Daitsiotis, B. Vitoux and M. Marraud, Peptides 1988, 20th Eur. Pept. Symp. (E. Bayer and G. Jung, Eds), Walter de Gruyter, Berlin, pp.489-500 (1989).

  5.  “FT-IR Study of the Tyr Hydroxyl Vibrations in Leu-enkephalin in Aqueous Solution”. N. Birlirakis, I.P. Gerothanassis, C. Sakarellos and M. Marraud, Peptides 1988, 20th Eur. Pept. Symp. (E. Bayer and G. Jung, Eds.), Walter de Gruyter, Berlin, pp. 504-506 (1989).

  4.  “A Novel Combined Use of 17O and IR Fourier Transform Spectroscopies as a Tool to Study Side-Chain Conformation of Phenol and Tyrosine Derivatives”. N. Birlirakis, I.P. Gerothanassis, C. Sakarellos and M. Marraud, 2eme Forum Peptides, John Libbey, Vol.174, pp.439-442 (1989).

  3.  “Oxygen-17 NMR Studies of Enkephalins in Aqueous and Organic Solutions”. C. Sakarellos, I.P. Gerothanassis, N. Birlirakis, T. Karayannis, M. Sakarellos-Daitsiotis and M. Marraud, 2eme Forum Peptides (A. Aubry, M. Marraud and B. Vitoux), John Libbey, Vol. 174, pp.403-406 (1989).

  2.  “Oxygen-17 NMR Studies of Enkephalins in Aqueous Solution”. I.P. Gerothanassis, T. Karayannis, M. Sakarellos-Daitsiotis, C. Sakarellos and M. Marraud, Peptides 1986, Proc.19th Eur. Pept. Symp., pp. 299-302 (D. Theodoropoulos, ed.), Walter de Gruyter, Berlin (1987).

  1.       “Fourier Transform Nuclear Magnetic Resonance Spectroscopy: Determination of Optimal Parameters in the Gaussian-Exponential Resolution Enhancement Technique”. I.P. Gerothanassis, G. Braudakis and J. Lauterwein, in Methods and Applications of Measurement and Control, (S.G. Tzafestas and M.H. Hamza, Eds), Vol.1, pp.202-205 Acta Press, Canada (1984).

Research Programs

Total financial support of the Research Projects 39-24 and 22-1 is over 1,500,000 €

39. “Bionian CLUSTER, Creation of innovative clusters - A Greek Product, One Market: The Planet”, ESPA 2007-2013. Collaborative project/subcontract, Coordinator: Prof. I.P. Gerothanassis (2013-2015).

38.  “Investigation of the Role of Iron in the Mechanisms of Intracellular Redox-Signaling through Oxidation of Cysteine Residues in Proteins”. Coordinator: Prof. D. Galanis, Research Program THALIS 1356, ESPA 2007-2013 (2013-2015).

37. “Cleaning Wastewater Systems and Microalgae Biomass to Produce Biofuels and Biochemicals Third Generation High Value Products”. Coordinator: Ass. Prof. H. Stamatis. Operational program Thessaly-Central Greece-Epirus 2007-2013 Research and Technological Development, Region of Epirus (2012-2014).

36. “Authenticity and Originality of Milk (AUORMI)”. Coordinator: Ass. Prof. C. Papachristoforou (Cyprus Univ. of Technology). Program financed by VIVARTIA. Scientific cooperation between Cyprus Univ. of Technology, UoI & VIVARTIA (2012).

35. “Improvement of Lipid Fraction in Ovine Milk and Halloumi Cheese towards Healthier Local Products” Coordinator: Ass. Prof. C. Papachristoforou (Cyprus Univ. of Technology). Health and Biological Sciences. Action: Food Science & Biotechnology. Cooperation program founded by the Research Promotion Foundation (2012-2013).

34. “Interaction of Intrinsically Disordered Proteins which are Implicated in Cancer with Compounds of Pharmaceutical Interest from Plant Extracts from Epirus”. Coordinator: Ass. Prof. E. Briasoulis, Foundation Joseph Ester Gani (2011-2012).

33. “High Sensitivity Cryo-NMR and LC-SPE-cryo-NMR Studies and Investigation of Anti-proliferation and Anti-angiogenesis Properties of Natural Products”. Coordinator: Prof. I.P. Gerothanassis, HERACLETOS PhD Program, Greek Ministry of Education, Life Long Learning & Religious Affairs (2010-2013).

32. “ΝΜR Studies of the Composition in Terpenoids of Natural Extracts from Plants from the Region of Epirus”. Coordinator: Prof. I.P. Gerothanassis, Foundation Joseph Ester Gani (2008-2009).

31. “Creation of a Cross-Border Center which Supports the Means of Mass Communication for the Standardization, Commercialization and Certification of Traditional Products”. Coordinator: Prof. G. Pilidis, INTEREG III (2006-2008).

30. “Synthesis and Biological Evaluation of Peptide Analogues of MBP”. Coordinator: Prof. I. Matsoukas, PENED 2003, Greek General Secretariat of Research and Technology (2006-2008).

29. “Development of Hyphenated Chromatographic and NMR Methodologies for the Investigation of Bioactive Compounds in Natural Products”. Coordinator: Prof. I.P. Gerothanassis, PENED 2003, Greek General Secretariat of Research and Technology (2006-2008).

28. “Improvement of Health with New Methods of Prevention and Diagnosis”. Coordinator: Prof. I.P. Gerothanassis, Program Hermes, Week for Research and Technology, Greek General Secretariat of Research and Technology (2005).

27. “Studies of Olive Oil Leafs: Physico-Chemical Studies and Antiproliferative Activity”. Coordinator: Prof. I.P. Gerothanassis, PYTHAGORAS Postgraduate Program, Greek Ministry of Education & Religious Affairs (2004-2006).

26. “The Renin - Angiotensin – Aldosterone System: The Molecular Basis of Hypertention by the Use of NMR and Theoretical Calculations”. Coordinator: Prof. I.P. Gerothanassis, HERACLETOS PhD Program, Greek Ministry of Education & Religious Affairs (2002-2005).

25. “Qualitative and Quantitative Determination of Flavonoids in Complex Natural Extracts with the Use of Hyphenated NMR Techniques”. Coordinator: Prof. I.P. Gerothanassis, Greece-Germany IKYDA 2002, Collaborative Research Grant (2002-2003).

24. “Development of an Innovative Antidepressive Drug from Hypericum Perforatum of Epirus”. Coordinator: Prof. I.P. Gerothanassis, PENED 2001, Greek General Secretariat of Research and Technology (2002-2005).

23. “EPEAEK: Dept. of Biological Applications & Technologies”. Coordinator: Prof. I.P. Gerothanassis, Greek Ministry of Education & Religious Affairs (1999-2004).

22. “Angiotensin Converting Enzyme (ΑCE) – The Role of Zn in the Catalytic Activities”. Coordinator: Prof. I.P. Gerothanassis, PENED 99, Greek General Secretariat of Research and Technology (1999-2001).

21. “Investigation of Phenolic Antioxidant Compounds and their Bioavailability in Food of Mediterranean Diet”. Coordinator: Prof. D. Boskou, Aristotle Univ. of Thessaloniki, EPET ΙΙ, Greek General Secretariat of Research and Technology (1999-2001).

20. “Multinuclear (1H, 13C, 15N, 17O and 57Fe) Μagnetic Resonance Studies of Five-and Six- Coordinated Hemoproteins & Synthetic Model Compounds”. Coordinator: Prof. I.P. Gerothanassis, Collaborative Program of Research and Technology (Greece-Italy), Greek General Secretariat of Research and Technology (1999-2001).

19. “Peptide Mimetics, New Generation of Pharmaceutical Products. Pilot Production of Angiotensin Inhibitors – New Generation of Anti-Hypertensive Drugs”. Coordinator: Prof. I. Matsoukas, EKVAN 1999, Greek General Secretariat of Research and Technology (1999-2001).

18. “NMR Studies of Individual Water Molecules Bound to Cis/Trans Amides and Neurohypophyseal Peptide Hormones”. Coordinator: Prof. I.P. Gerothanassis, NATO Scientific Affairs Division, Collaborative Research Grants Program (New) (1997).

17. “Multinuclear and Multidimensional NMR and Theoretical Studies of O2 and CO Carriers in Myoglobins, Hemoglobins, Cytochrome P-450 and Synthetic Analogues in Biomimetic Catalysis”. Coordinator: Ass. Prof. I.P. Gerothanassis, PENED 1995, Greek General Secretariat of Research and Technology (1995-1996).

16. “Synthesis and Multinuclear NMR Spectroscopic Studies in the Solid of Hemoproteins and Model Compounds of the Active Site of Hemoproteins”. Coordinator: Ass. Prof. I.P. Gerothanassis, Collaborative Research and Technology Program (Greece-France), Greek General Secretariat of Research and Technology (1995).

15. “Ab Initio and Heteronuclear 1H–15N Multiple Quantum Coherence NMR Studies of Amide-Water Clusters”. Coordinator: Ass. Prof. I.P. Gerothanassis, NATO Scientific Affairs Division, Priority Area on High Technology (1995).

14. “High Field NMR Investigation of the Chain-Breaking Antioxidant Capacity of Biological Fluids: The Influence of Synthetic Dietary Antioxidants”. Coordinator: Dr. G. Hawkes, EC Agriculture and Agro-industry including Fisheries, Directorate General VI, XII, XIV (1994-1996). Contributing Institutions: (i) Dept. of Chemistry, Queen Mary and Westfield College, London (Dr. G. Hawkes). (ii) London Hospital Medical College (Dr. M. Grootveld). (iii) Dipartimento di Chimica Inorganica, Chimica Fisica e Chimica dei Materiali, Univ. of Torino, Italy (Prof. S. Aime).

13. “IR, Multinuclear, Multiple Quantum and Multidimensional NMR Spectroscopic Studies of Individual Solvation Molecules of Water of Peptide Hormones and Comple-xes of DHFR-NADPH-Methobrexate”. Coordinator: Ass. Prof. I.P. Gerothanassis, PENED 1991, Greek General Secretariat of Research and Technology (1994-1996).

12. “Synthesis and Multinuclear NMR Spectroscopic Studies in the Solid Model Compounds of the Active Site of Hemoproteins”. Coordinator: Ass. Prof. I.P. Gerothanassis, Collaborative Research Grant Greece-France, Ministry of Research and Development (1994).

11. “Synthesis and Structural Characterization of Oxygen and Carbonmonoxide Supramo-lecular Carriers Related to Biological Systems”. Coordinator: Dr. M. Momenteau, NATO Scientific Affairs Division, Collaborative Research Grant-Supramolecular (1992-1994).

10. “Synthesis and NMR Spectroscopic Studies of Model Compounds of the Active site of Hemoproteins”. Coordinator: Ass. Prof. I.P. Gerothanassis, Research Grant Greece-France, Ministry of Research and Development (1992-1993).

  9. “Protein 1H Assignments of L.casei Dihydrofolate Reductase in the Absence of Ligands Using Isotopic Labeling and 2D/3D NMR Techniques. Identification and Localization of Individual Solvation Water Molecules on DHFR-Ligand Complexes Using Isotopic Labeling and 2D/3D NMR Techniques”. Coordinator: Dr. J. Feeney, Welcome Trust, U.K. (1991).

  8. “Synthesis and NMR Spectroscopic Studies of: (i) Heterocyclic Compounds with Antiglaucomatic and Antispasmic Pharmacological Action. (ii) Model Compounds of the Active Site of Cytochrome P-450 and Myoglobin”. Coordinator: Ass. Prof. I.P. Gerothanassis, Research Committee of the UoI (1990-1992).

  7. “Protein 1H Assignments for L.cacei Dihydrofolate Reductase Using Isotopic Labeling and 2D/3D NMR Techniques”. Coordinator: Dr. J.Feeney, Welcome Trust, UK (1989).

  6. “Conformational Studies of Enkephalin Analogues in Biological Membranes – Spectroscopic Studies of Oxygen Carriers”. Coordinator: Ass. Prof. I.P. Gerothanassis, Research Committee of the UoI (1989-1991).

  5. “17O NMR Spectroscopy of Synthetic O2 and CO Carriers Related to Biological Systems”. Coordinator: Dr. M. Momenteau, NATO Scientific Affairs Division, Collaborative Research Grant (1989-1992).

  4. “17O NMR Spectroscopy as a Tool for Studying Synthetic Oxygen Carriers Related to Biological Systems”. Coordinator: Ass. Prof. I.P. Gerothanassis, Commission of the European Communities, Stimulation Action, Visite de Courte Duree (1988). Contributing Institutions: (i) Laboratory of Organic Chemistry, Dept. of Chemistry, UoI, (ii) Institut Curie, Section de Biologie, Orsay, France.

  3. “Synthèse et Etude Spectroscopique de Peptides Bioactifs: Hormonaux, Polypeptides, Substrats et Inhibiteurs des Enzymes Protéolytiques”. Coordinator: Prof. C. Sakarellos, Commission des Communautés Européennes, Direction General, Science, Recherche et Développement, Direction A “Action de Stimulation” Bruxelles (1985-1988). Contributing Institutions: (i) Section of Organic Chemistry and Biochemistry, Dept. of Chemistry, UoI (Prof. C. Sakarellos). (ii) Section of Physical Chemistry, Dept. of Chemistry, UoI (Ass. Prof. I.P. Gerothanassis). (iii) Laboratoire de Peptides, Service de Biochimie, Département de Biologie, Saclay (Dr. S. Fermandjian). (iv) Laboratoire de Chimie-Physique Macromoléculaire, Nancy (Dr. M. Marraud). (v) Laboratoire de Minéralogie et Cristallographie, Université de Nancy (Dr. A. Aubry).

  2. “Synthèse et Etude Spectroscopique de Peptides Hormonaux”. Coordinator: Prof. C. Sakarellos, Collaborative Research Grant Greece-France, Ministry of Research and Development (1985-1987).

  1.       “Studies of Nuclear Magnetic Resonance (NMR) Oxygen-17 and Election Spin (ESR)”. Coordinator: Dr. I.P. Gerothanassis, Research Committee of the UoI (1985-1987).

Programs for Research Infrastructure and Promotion of Research

Excellent research requires world-leading facilities which are becoming increasingly expensive and sophisticated. As a Rector of the UoI I have applied centrally several well documented specific research infrastructure projects and played a major role in the formulation and implementation of the research strategy policy of the Greek National Research Foundation in the Region of Epirus. As result, very significant support for research infrastructure was award to the University of Ioannina as follows:

Year

2005

3.000.000

2009 (July)

2.000.000

2009 (September)

2.000.000

The success rate of the applications was 100%.

http://nmrcenter.uoi.gr/index.php?option=com_content&view=article&id=93&Itemid=126&lang=en

Experience in Quality Assurance in Higher Education

General

During the last eight (8) years:

  • as a Rector of the University of Ioannina in the period 2006-2010,
  • as a member of the Hellenic Quality Assurance and Accreditation Agency (2010-present)

I have gained considerable experience of internal and external quality assurance systems of Higher Education Institutions (HEIs) and curricula of higher education.

Quality Assurance in the University of Ioannina

The University of Ioannina in close collaboration with the Hellenic Quality Assurance and Accreditation Agency (established by Low in 2005), became the prototype institution for the implementation of both internal and external evaluation procedures:

  • The University of Ioannina was the first one among the Greek Universities to proceed with the internal evaluation of the whole Institution with a decision of the Senate (June 2008).
  • The University of Ioannina was the first one among the Greek Universities to submit the institutional Internal Evaluation to the Hellenic Quality Assurance and Accreditation Agency for Higher Education (HQAA) (October 2009, Revised version April 2010).
  • Fifteen Departments of the University among seventeen, submitted Internal Evaluation Reports (IER) to the Hellenic Quality Assurance and Accreditation Agency for Higher Education in the period June 2009-September 2010.
  • The Department of Physics of the University of Ioannina was evaluated in June 2010 from an international External Evaluation Committee, and the evaluation of five more Departments was completed in 2011.
  • The University of Ioannina was the only Greek University which participated both in 2005 and 2009 in European Universities Association (EUA) study cases.

Experience as a Member of the Council of HQAA

Ι. Evaluation procedures in the field of Natural Sciences

Since September 2010 I have been a member of the Council of HQAA with responsibilities in the area of natural sciences (mathematics, physics, chemistry, material sciences and engineering, computer sciences and environmental sciences). During the period September 2010 until February 2014, forty (40) Departments have been successfully evaluated under my supervision with internationally recognized external evaluators from USA, Canada and Europe.

ΙI. Accreditation procedures

As a representative of HQAA in the “National Committee of the Referencing process of the Hellenic National Qualifications Framework (HNQF) to the European Qualifications Framework (EQF)”, I have gained considerable experience of the European Qualifications Framework and National Qualifications and Accreditation frameworks of several European Countries.

 

 

Research Infrastructure

NMR Center

The NMR Center is lodged in two specially tided up rooms, in the Department of Chemistry of the University of Ioannina. The instrumentation consists of:

  • A Brüker AV-250 spectrometer (resonance frequency of 1H 250 MHz), installed in 1999, updated in 2006.
  • A Brüker AV-400 spectrometer (resonance frequency of 1H 400 MHz), installed in 1994, updated in 2006, with the capabilities of obtaining high-resolution spectra in the liquid and solution state.
  • A Brüker AV-500 hyphenated with an LC-SPE system, the latter equipped with a solvent delivery pump, a DAD UV detector and a Prospect 2 solid phase extraction (SPE) unit. All individual components are connected in line to produce LC-SPE-UV-NMR hyphenation. This modern instrumentation was sponsored in 2005 by the Greek Community Support Framework III, Regional Operational Program of Epirus 2000–2006 (MIS 91629). Moreover the AV500 was equipped with a cryogenic platform and a cryo TXI -probe head. The latter can be easily converted to flow probe and work in flow mode after the necessary modification through the mounting of a flow inlet. The AV-500 is also equipped with an autosampler fully controlled by the Topspin suite (ICON-NMR).

All spectrometers have probes that are optimised for 1H applications and probes that are capable of multinuclear detection. The running cost of the instruments of the Center is about 16.900 € per year. The outlet of the fixed consumables (liquid He and liquid N2) and the repairing of the instruments are covered by the budget of the University of Ioannina.

Computational Facilities

Three workstations are available to the users for data manipulation. The two of them have the Topspin suite and the third has additionally the AMIX –Aurelia suite.

 

 

 

 

 

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